Moschos Marilita M, Dettoraki Maria, Androudi Sofia, Kalogeropoulos Dimitrios, Lavaris Anastasios, Garmpis Nikolaos, Damaskos Christos, Garmpi Anna, Tsatsos Michael
First Department of Ophthalmology, G. Gennimatas General Hospital of Athens, Medical School, National and Kapodistrian University of Athens, Athens, Greece
First Department of Ophthalmology, G. Gennimatas General Hospital of Athens, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
Anticancer Res. 2018 Jul;38(7):3817-3824. doi: 10.21873/anticanres.12665.
Uveal melanoma is the most common intraocular malignancy in adults, representing approximately 3% of all melanoma cases. Despite progress in chemotherapy, radiation and surgical treatment options, the prognosis and survival rates remain poor. Acetylation of histone proteins causes transcription of genes involved in cell growth, DNA replication and progression of cell cycle. Overexpression of histone deacetylases occurs in a wide spectrum of malignancies. Histone deacetylase inhibitors block the action of histone deacetylases, leading to inhibition of tumor cell proliferation. This article reviewed the potential therapeutic effects of histone deacetylase inhibitors on uveal melanoma. MEDLINE database was used under the key words/phrases: histone deacetylase, inhibitors, uveal melanoma and targeted therapies for uveal melanoma. A total of 47, English articles, not only referring to uveal melanoma, published up to February 2018 were used. Valproic acid, trichostatin A, tenovin-6, depsipeptide, panobinostat (LBH-589), vorinostat (suberanilohydroxamic acid) entinostat (MS-275), quisinostat, NaB, JSL-1, MC1568 and MC1575 are histone deacetylase inhibitors that have demonstrated promising antitumor effects against uveal melanoma. Histone deacetylase inhibitors represent a promising therapeutic approach for the treatment of uveal melanoma.
葡萄膜黑色素瘤是成人中最常见的眼内恶性肿瘤，约占所有黑色素瘤病例的3%。尽管在化疗、放疗和手术治疗方面取得了进展，但预后和生存率仍然很差。组蛋白的乙酰化会导致参与细胞生长、DNA复制和细胞周期进程的基因转录。组蛋白去乙酰化酶的过表达发生在多种恶性肿瘤中。组蛋白去乙酰化酶抑制剂可阻断组蛋白去乙酰化酶的作用，从而抑制肿瘤细胞增殖。本文综述了组蛋白去乙酰化酶抑制剂对葡萄膜黑色素瘤的潜在治疗作用。使用MEDLINE数据库，关键词为：组蛋白去乙酰化酶、抑制剂、葡萄膜黑色素瘤和葡萄膜黑色素瘤的靶向治疗。共使用了截至2018年2月发表的47篇英文文章，这些文章不仅涉及葡萄膜黑色素瘤。丙戊酸、曲古抑菌素A、替尼泊苷-6、缩肽、帕比司他（LBH-589）、伏立诺他（辛二酰苯胺异羟肟酸）、恩替诺特（MS-275）、喹西他特、丁酸钠、JSL-1、MC1568和MC1575是组蛋白去乙酰化酶抑制剂，它们已显示出对葡萄膜黑色素瘤有良好的抗肿瘤作用。组蛋白去乙酰化酶抑制剂是治疗葡萄膜黑色素瘤的一种有前景的治疗方法。
