Hasegawa A, Yamashita H, Kondo S, Kiyota T, Hayashi H, Yoshizaki H, Murakami A, Shiratsuchi M, Mori T
Life Science Research Laboratories, Asahi Chemical Industry Co., Ltd., Shizuoka, Japan.
Biochem Biophys Res Commun. 1988 Feb 15;150(3):1230-6. doi: 10.1016/0006-291x(88)90760-7.
Proteose peptone markedly enhanced the production of human tissue-type plasminogen activator (t-PA) from confluently cultured cell of human diploid fibroblasts. The cells continued synthesizing and secreting high levels of t-PA under periodic replacement of medium containing proteose peptone for more than one month. The highly increased activity correlated with equally increased levels of t-PA antigen and concomitantly increased levels of t-PA specific mRNA.
蛋白胨显著增强了人二倍体成纤维细胞汇合培养细胞中人组织型纤溶酶原激活物（t-PA）的产生。在含有蛋白胨的培养基定期更换的情况下，细胞持续合成和分泌高水平的t-PA超过一个月。高度增加的活性与t-PA抗原水平的同等增加以及t-PA特异性mRNA水平的相应增加相关。
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