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老问题重现:一例未接种疫苗患者的破伤风病例。

Return of the old guard: a case of tetanus in an unvaccinated patient.

作者信息

Ibe Uzochukwu, Rehmani Sameerah, Jiwa Nasheena, Gega Arjet

机构信息

Internal Medicine, St. Mary's Hospital, Waterbury, Connecticut, USA.

Infectious Disease, St. Mary's Hospital, Waterbury, Connecticut, USA.

出版信息

BMJ Case Rep. 2019 Jun 26;12(6):e229502. doi: 10.1136/bcr-2019-229502.

Abstract

A 78-year-old woman with no known medical history presented with severe neck pain that began 4 days prior to admission located in the paraspinal cervical region radiating to the shoulders, legs and back. She had associated stiffness of her neck and progression of pain to her jaw and throat with progression to generalised body spasms with lower extremity stiffness and weakness that limited her ability to walk. She quickly developed dysphagia and odynophagia with subsequent generalised spasms and profound hypoxic respiratory failure requiring nasotracheal intubation. The presumptive diagnosis of tetanus was made and she was given tetanus toxoid immune globulin and Tdap vaccine. She was managed in the intensive care unit and after a week of admission, required a tracheostomy and gastrostomy tube placement. She required a prolonged hospitalisation stay of 21 days before being transferred to a long-term vent facility.

摘要

一名78岁、无已知病史的女性,因入院前4天开始出现严重颈部疼痛而就诊,疼痛位于颈椎旁区域,放射至肩部、腿部和背部。她伴有颈部僵硬,疼痛逐渐蔓延至下颌和喉咙,并发展为全身痉挛,伴有下肢僵硬和无力,限制了她的行走能力。她很快出现吞咽困难和吞咽痛,随后出现全身痉挛和严重的低氧性呼吸衰竭,需要经鼻气管插管。初步诊断为破伤风,并给予破伤风类毒素免疫球蛋白和破伤风、白喉、百日咳联合疫苗。她在重症监护病房接受治疗,入院一周后,需要进行气管切开术和胃造瘘管置入术。在转至长期通气设施之前,她需要住院21天。

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