Yen Cynthia, Murray Erin, Zipprich Jennifer, Winter Kathleen, Harriman Kathleen
MMWR Morb Mortal Wkly Rep. 2015 Mar 13;64(9):243-6.
Tetanus is an acute and sometimes fatal disease characterized by sudden muscle contractions. The number of tetanus cases reported annually in the United States has declined significantly since the 1930s and 1940s as a result of the introduction of tetanus vaccines. However, sporadic cases continue to occur in persons who are not up-to-date with tetanus toxoid-containing vaccinations (TT) and do not receive appropriate postexposure prophylaxis (PEP). To assess the extent of these cases, the California Department of Public Health reviewed all tetanus cases reported during January 2008-March 2014. A total of 21 tetanus patients were reported; five (24%) died. An average of three cases were reported each year during 2008-2013; the average annual incidence among patients aged ≥65 years (0.23 cases per 1 million population) was twice that among patients aged 21-64 years (0.10 cases per 1 million population). Of 16 patients with an acute injury before illness and diagnosis, nine (56%) sought medical care, and two (22%) of the nine received appropriate PEP. Although tetanus is rare, it is a life-threatening disease that is preventable. Health care providers should ensure that their patients are up-to-date with TT vaccination and provide appropriate postexposure prophylaxis for patients with wounds.
破伤风是一种急性疾病,有时甚至会致命,其特征为肌肉突然收缩。自20世纪30年代和40年代引入破伤风疫苗以来,美国每年报告的破伤风病例数量显著下降。然而,在未及时接种含破伤风类毒素疫苗(TT)且未接受适当暴露后预防措施(PEP)的人群中,仍有散发病例出现。为评估这些病例的情况,加利福尼亚州公共卫生部审查了2008年1月至2014年3月期间报告的所有破伤风病例。共报告了21例破伤风患者;其中5例(24%)死亡。2008 - 2013年期间平均每年报告3例;≥65岁患者的年平均发病率(每百万人口0.23例)是21 - 64岁患者(每百万人口0.10例)的两倍。在16例发病和诊断前有急性损伤的患者中,9例(56%)寻求了医疗护理,其中9例中的2例(22%)接受了适当的PEP。尽管破伤风很罕见,但它是一种可预防的危及生命的疾病。医疗保健提供者应确保其患者及时接种TT疫苗,并为伤口患者提供适当的暴露后预防措施。