Martini Francesca, Cecconi Nadia, Paolicchi Aldo, Galimberti Sara, Cervetti Giulia, Buda Gabriele, Petrini Mario
Department of Clinical and Experimental Medicine, U.O. Hematology, University of Pisa, Pisa, Italy.
TH Open. 2019 Mar 19;3(1):e64-e66. doi: 10.1055/s-0039-1683969. eCollection 2019 Jan.
Abnormal coagulation properties indicative of a dysfibrinogenemia were found in the plasma of an asymptomatic 65-year-old male. An immunoglobulin k light chain was found to interfere with Fg functional assay and coagulation tests (activated partial thromboplastin time, prothrombin time, and thrombin time). Steroid therapy reduced the inhibitory effect (after dexamethasone treatment coagulation test and functional Fg value normalized). Spurious dysfibrinogenemia associated with light chain monoclonal gammopathy of undetermined significance was diagnosed.
在一名无症状的65岁男性血浆中发现了提示异常纤维蛋白原血症的异常凝血特性。发现一种免疫球蛋白κ轻链干扰纤维蛋白原（Fg）功能测定和凝血试验（活化部分凝血活酶时间、凝血酶原时间和凝血酶时间）。类固醇治疗降低了抑制作用（地塞米松治疗后凝血试验和功能性Fg值恢复正常）。诊断为与意义未明的轻链单克隆丙种球蛋白病相关的假性异常纤维蛋白原血症。
