Finger H, Drechsler H J, Wirsing von König C H
Städtische Krankenanstalten Krefeld, Institut für Hygiene und Laboratoriumsmedizin.
Immun Infekt. 1987 Nov;15(6):208-15.
The immunohaematology results found during antenatal care from 1963-1981 were used to try to answer the question whether and how much the anti-D-prophylaxis, which was started in 1967 and was given to German and foreign pregnant women post partum or after abortion, had affected the frequency of immunization to D and other erythrocyte antigens. The results allow the following statements: 1. From 1973-3 or 4 years after the general introduction of anti-D prophylaxis-until 1981, a continuously sustained decline in the frequency of anti-D in the German pregnant women was found. This could not be found in the corresponding group of foreign pregnant mothers. 2. Additionally, a statistically significant reduction in the frequency of anti-D + C could only be found in the German group. 3. After 1973, other erythrocyte antibodies in combination with anti-D were only found sporadically. A rise in the frequency of other erythrocyte antibodies, such as anti-C, was not observed. 4. The frequency of "non-anti-D antibodies" was significantly higher in the foreigners than in the German group during the whole observation period. This was due to the significant increase in anti-Lea, anti-Leb, anti-H, anti-P1 and the nonidentifiable antibodies in the foreign group.
1963年至1981年产前检查期间的免疫血液学结果被用于尝试回答以下问题：1967年开始并给予德国和外国孕妇产后或流产后使用的抗D预防措施是否以及在多大程度上影响了对D及其他红细胞抗原的免疫频率。结果如下：1. 从1973年（即抗D预防措施普遍推行3或4年后）到1981年，发现德国孕妇中抗D频率持续下降。在相应的外国孕妇组中未发现这种情况。2. 此外，仅在德国组中发现抗D + C频率有统计学意义的降低。3. 1973年后，其他红细胞抗体与抗D同时出现的情况仅偶尔发现。未观察到其他红细胞抗体（如抗C）频率的上升。4. 在整个观察期内，外国人群中“非抗D抗体”的频率显著高于德国组。这是由于外国组中抗Lea、抗Leb、抗H、抗P1及无法识别的抗体显著增加所致。
