Hähn N, Gallasch E H, Wilken H
Zentralbl Gynakol. 1976;98(1):39-44.
The effectivity of the anti-D-prophylaxis performed at the Women's Hospital of the University of Göttingen was controlled by means of serological control examinations of those women, who represented an increase immunological risk of a potential formation of antibodies by means of a second and third Rh-positive infant. None of these women showed an anti-D-body-formation in spite of the application of very sensitive serological methods of examination. In about 10% of our examined women the standard dosis of 300 mug anti-D-IgG had to be increased, so as to achieve a complete elimination of fetal erythrocytes. This result underlines again the necessity of a careful control of influx of red blood corpuscles after the application of anti-D-IgG, so as to avoid failures of the applied prophylaxis. Though we are not in the position to give a final answer concerning the effectivity of our anti-D-prophylaxis with the control examination of 58 serologically observed women, we are of the opinion, that the special immunological stress of a second or third delivery in this special group of patients puts more weight to the observation. As there were no "failures" in these exposed patients to be found by means of the differentiated serological tests during the control examinations, we believe, that our anti-D-prophylaxis-scheme appears to be effective from the present point of view.
哥廷根大学妇女医院实施的抗D预防措施的有效性，通过对那些因第二次和第三次怀有Rh阳性婴儿而存在潜在抗体形成免疫风险增加的女性进行血清学对照检查来控制。尽管应用了非常敏感的血清学检测方法，但这些女性中没有一人出现抗D抗体形成。在我们检查的女性中，约10%的人必须增加300微克抗D-IgG的标准剂量，以实现胎儿红细胞的完全清除。这一结果再次强调了在应用抗D-IgG后仔细控制红细胞流入的必要性，以避免所应用预防措施的失败。虽然我们无法通过对58名血清学观察女性的对照检查就我们的抗D预防措施的有效性给出最终答案，但我们认为，这一特殊患者群体中第二次或第三次分娩的特殊免疫应激使观察更为重要。由于在对照检查期间通过差异化血清学检测在这些暴露患者中未发现“失败”情况，我们相信，从目前的角度来看，我们的抗D预防方案似乎是有效的。
