Department of Marine Life Sciences, Jeju National University, Jeju Self-Governing Province 63243, Republic of Korea; Marine Science Institute, Jeju National University, Jeju Self-Governing Province 63333, Republic of Korea.
Freshwater Bioresources Utilization Division, Nakdonggang National Institute of Biological Resources, Sangju 37242, Republic of Korea.
Environ Pollut. 2019 Sep;252(Pt B):1318-1324. doi: 10.1016/j.envpol.2019.06.029. Epub 2019 Jun 14.
The increase in ambient fine dust particles (FDP) due to urbanization and industrialization has been identified as a major contributor to air pollution. It has become a serious issue that threatens human health because it causes respiratory diseases and skin aging. In the present study, the protective effect of the green tea catechin, (-)-epigallocatechin gallate (EGCG), against FDP (ERM-CZ100)-stimulated skin aging in human dermal fibroblasts (HDFs) was investigated. The results demonstrate that EGCG significantly and dose-dependently scavenged intracellular reactive oxygen species (ROS) in and increased the viability of FDP-stimulated HDFs. In addition, EGCG dose-dependently recovered collagen synthesis and inhibited intracellular elastase and collagenase activities. Moreover, EGCG decreased the expression of human matrix metalloproteinases (MMPs) via regulation of nuclear factor kappa B (NF-κB), activator protein 1 (AP-1), and mitogen-activated protein kinases (MAPKs) signaling pathways in FDP-stimulated HDFs. This study suggests that EGCG is a potential anti-aging candidate that can be used for FDP-induced skin aging as a therapeutic agent itself or as an ingredient in pharmaceutical and cosmeceutical products.
由于城市化和工业化，环境中细粉尘颗粒（FDP）的增加已被确定为空气污染的主要原因。它已成为一个严重的问题，威胁着人类健康，因为它会导致呼吸道疾病和皮肤老化。在本研究中，研究了绿茶儿茶素（-）-表没食子儿茶素没食子酸酯（EGCG）对人真皮成纤维细胞（HDF）中 FDP（ERM-CZ100）刺激的皮肤衰老的保护作用。结果表明，EGCG 可显著且剂量依赖性地清除细胞内活性氧（ROS），并增加 FDP 刺激的 HDF 的活力。此外，EGCG 剂量依赖性地恢复胶原蛋白合成，并抑制细胞内弹性蛋白酶和胶原酶活性。此外，EGCG 通过调节核因子 kappa B（NF-κB）、激活蛋白 1（AP-1）和丝裂原活化蛋白激酶（MAPKs）信号通路，降低了 FDP 刺激的 HDF 中人基质金属蛋白酶（MMPs）的表达。这项研究表明，EGCG 是一种潜在的抗衰老候选物，可作为治疗剂本身或作为药物和化妆品产品的成分，用于 FDP 诱导的皮肤衰老。
