Han Hye Sung, Seok Joon, Park Kui Young
Department of Dermatology, Chung-Ang University College of Medicine, Seoul, Korea.
Institute of Clinical Medicine, Chung-Ang University Gwangmyeong Hospital, Gwangmyeong, Korea.
Ann Dermatol. 2025 Apr;37(2):53-67. doi: 10.5021/ad.24.159.
Air pollution is a widespread environmental issue, with substantial global implications for human health. Recent epidemiological studies have shown that exposure to air pollution exacerbates various inflammatory skin conditions, including atopic dermatitis, psoriasis, or acne. Furthermore, air pollutants are associated with accelerated skin aging, hair loss, and skin cancer. The aim of this review is to elucidate the current understanding of the impact of air pollution on skin health, emphasizing the underlying mechanisms involved and existing therapeutic and cosmetic interventions available to prevent or mitigate these effects. A pivotal factor in the harmful effects of air pollution is the formation of reactive oxygen species and the resulting oxidative stress. The aryl hydrocarbon receptor signaling pathway also substantially contributes to mediating the effects of air pollutants on various skin conditions. Moreover, air pollutants can disrupt the skin barrier function and trigger inflammation. Consequently, antioxidant and anti-inflammatory therapies, along with treatments designed to restore the skin barrier function, have the potential to mitigate the adverse effects of air pollutants on skin health.
空气污染是一个普遍存在的环境问题，对全球人类健康有着重大影响。最近的流行病学研究表明，接触空气污染会加剧各种炎症性皮肤病，包括特应性皮炎、银屑病或痤疮。此外，空气污染物还与皮肤加速老化、脱发和皮肤癌有关。本综述的目的是阐明目前对空气污染对皮肤健康影响的理解，强调其中涉及的潜在机制以及现有的预防或减轻这些影响的治疗和美容干预措施。空气污染有害影响的一个关键因素是活性氧的形成以及由此产生的氧化应激。芳烃受体信号通路也在很大程度上有助于介导空气污染物对各种皮肤状况的影响。此外，空气污染物会破坏皮肤屏障功能并引发炎症。因此，抗氧化和抗炎疗法以及旨在恢复皮肤屏障功能的治疗方法有可能减轻空气污染物对皮肤健康的不利影响。
