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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Wollenberg P, Rummel W

Institut für Pharmakologie and Toxikologie, Universität des Saarlandes, Homburg/Saar, Federal Republic of Germany.

Naunyn Schmiedebergs Arch Pharmacol. 1987 Nov;336(5):578-82. doi: 10.1007/BF00169317.

In rats iron was absorbed after administration into the gut lumen as ferric iron bound to serum albumin, to nitrilotriacetic acid, and to 8-OH-quinoline sulfonic acid, or as isolated diferri-transferrin. 2. Iron absorption from 59Fe-labelled transferrin was inhibited by the addition of rat plasma. 3. The inhibitory component in the rat plasma turned out to be ceruloplasmin (ferrous iron oxidase, EC 1.16.2.1). 4. The absorption of iron from these ferric iron complexes was also inhibited by addition to the incubation medium of ferrozine, a strong anionic Fe(II)-ligand. 5. Uptake and absorptive utilization of transferrin-bound ferric iron was decreased after a prewash of the gut lumen and could be restored by the addition of ascorbate to the incubation medium. 6. The conclusion was drawn from these results that luminal reduction precedes ferric iron absorption and that this is a prerequisite for the uptake into the mucosa.

在大鼠中，铁以与血清白蛋白、次氮基三乙酸和8-羟基喹啉磺酸结合的三价铁形式，或作为分离的二价铁转铁蛋白进入肠腔后被吸收。2. 添加大鼠血浆可抑制从59Fe标记的转铁蛋白中吸收铁。3. 结果表明，大鼠血浆中的抑制成分是铜蓝蛋白（亚铁氧化酶，EC 1.16.2.1）。4. 向孵育培养基中添加强力阴离子Fe(II)配体二氮杂菲，也会抑制这些三价铁络合物中铁的吸收。5. 肠腔预冲洗后，转铁蛋白结合的三价铁的摄取和吸收利用减少，向孵育培养基中添加抗坏血酸可恢复。6. 从这些结果得出的结论是，腔内还原先于三价铁吸收，这是其被黏膜摄取的前提条件。

Wollenberg P, Rummel W

Institut für Pharmakologie and Toxikologie, Universität des Saarlandes, Homburg/Saar, Federal Republic of Germany.

Naunyn Schmiedebergs Arch Pharmacol. 1987 Nov;336(5):578-82. doi: 10.1007/BF00169317.

In rats iron was absorbed after administration into the gut lumen as ferric iron bound to serum albumin, to nitrilotriacetic acid, and to 8-OH-quinoline sulfonic acid, or as isolated diferri-transferrin. 2. Iron absorption from 59Fe-labelled transferrin was inhibited by the addition of rat plasma. 3. The inhibitory component in the rat plasma turned out to be ceruloplasmin (ferrous iron oxidase, EC 1.16.2.1). 4. The absorption of iron from these ferric iron complexes was also inhibited by addition to the incubation medium of ferrozine, a strong anionic Fe(II)-ligand. 5. Uptake and absorptive utilization of transferrin-bound ferric iron was decreased after a prewash of the gut lumen and could be restored by the addition of ascorbate to the incubation medium. 6. The conclusion was drawn from these results that luminal reduction precedes ferric iron absorption and that this is a prerequisite for the uptake into the mucosa.

在大鼠中，铁以与血清白蛋白、次氮基三乙酸和8-羟基喹啉磺酸结合的三价铁形式，或作为分离的二价铁转铁蛋白进入肠腔后被吸收。2. 添加大鼠血浆可抑制从59Fe标记的转铁蛋白中吸收铁。3. 结果表明，大鼠血浆中的抑制成分是铜蓝蛋白（亚铁氧化酶，EC 1.16.2.1）。4. 向孵育培养基中添加强力阴离子Fe(II)配体二氮杂菲，也会抑制这些三价铁络合物中铁的吸收。5. 肠腔预冲洗后，转铁蛋白结合的三价铁的摄取和吸收利用减少，向孵育培养基中添加抗坏血酸可恢复。6. 从这些结果得出的结论是，腔内还原先于三价铁吸收，这是其被黏膜摄取的前提条件。