65 岁以下患者全髋关节和膝关节置换术前及术后的慢性处方阿片类药物使用情况。

Chronic Prescription Opioid Use Before and After Total Hip and Knee Arthroplasty in Patients Younger Than 65 Years.

机构信息

Department of Orthopaedic Surgery, Boston Medical Center, Boston, MA.

Department of Public Health and Community Medicine, Tufts University School of Medicine, Boston, MA.

出版信息

J Arthroplasty. 2019 Oct;34(10):2319-2323. doi: 10.1016/j.arth.2019.05.050. Epub 2019 Jun 1.

Abstract

BACKGROUND

Opioids are commonly prescribed to patients with painful and symptomatic degenerative joint disease preoperatively as a nonoperative intervention to reduce patients' symptoms and pain. The goal of total joint arthroplasty (TJA) is to reduce or eliminate the painful symptoms of degenerative joint disease. Due to the addictive property of opioid medications, some patients may develop a pattern of chronic opioid use after TJA.

METHODS

We used MarketScan Commercial Claims and Encounters database to identify 125,019 patients (age <65 years) who underwent total knee arthroplasty (TKA) and total hip arthroplasty (THA) between 2009 and 2012. During the study period, opioid use was analyzed 3 months before surgery and at 12 months after surgery. We defined chronic opioid use as having 2 or more opioid prescriptions filled within any 6-week period. Multivariate logistic regression was used.

RESULTS

Of the 24,127 patients who were chronic prescription opioid users before surgery, 72% were no longer chronic users 1 year after surgery. Of the 100,892 patients who were nonusers before surgery, 4% became chronic users within 1 year after surgery. TKA and hospital stay longer than 3 days were significant risk factors of persisting chronic opioid use after surgery, while age played a mixed role in predicting change of opioid use.

CONCLUSION

Using our definition of chronic use, overall chronic opioid use decreased from 19% to 9% after TJA. Patients were more likely to cease chronic opioid use after TJA (72%) than to become chronic users (4%).

摘要

背景

在术前,为了减轻患者的症状和疼痛,常给患有疼痛和症状性退行性关节疾病的患者开具阿片类药物作为非手术干预措施。全关节置换术(TJA)的目的是减轻或消除退行性关节疾病的疼痛症状。由于阿片类药物具有成瘾性,一些患者在 TJA 后可能会形成慢性阿片类药物使用模式。

方法

我们使用 MarketScan 商业索赔和就诊数据库,确定了 125019 名(<65 岁)在 2009 年至 2012 年间接受全膝关节置换术(TKA)和全髋关节置换术(THA)的患者。在研究期间,分析了手术前 3 个月和手术后 12 个月的阿片类药物使用情况。我们将慢性阿片类药物使用者定义为在任何 6 周内有 2 次或更多次阿片类药物处方的患者。采用多变量逻辑回归分析。

结果

在术前为慢性处方阿片类药物使用者的 24127 名患者中,72%的患者在术后 1 年内不再为慢性使用者。在术前为非使用者的 100892 名患者中,有 4%的患者在术后 1 年内成为慢性使用者。TKA 和住院时间超过 3 天是术后持续慢性阿片类药物使用的显著危险因素,而年龄在预测阿片类药物使用变化方面发挥了混合作用。

结论

使用我们的慢性使用定义,TJA 后总体慢性阿片类药物使用率从 19%降至 9%。与成为慢性使用者(4%)相比,患者更有可能在 TJA 后停止慢性阿片类药物使用(72%)。

文献AI研究员

20分钟写一篇综述,助力文献阅读效率提升50倍

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索