Department of Internal Medicine, Ribeirao Preto Medical School, University of São, Paulo, Ribeirão Preto, Brazil.
Department of Internal Medicine, Ribeirao Preto Medical School, University of São, Paulo, Ribeirão Preto, Brazil; Laboratory of Studies in Biochemistry and Molecular Biology, Department of Molecular Biology, São José do Rio Preto Medical School, Brazil.
Nutrition. 2019 Oct;66:115-121. doi: 10.1016/j.nut.2019.05.002. Epub 2019 May 24.
Telomeres are structures located at the ends of chromosomes associated with proteins, from the shelterin complex, which are responsible for the protection and preservation of the genetic material. The telomere length (TL) progressively decreases with each cell division, and recent evidence suggests that lifestyle can lead to telomere shortening. In individuals with obesity, excess adipose tissue plays a key role in inducing a chronic and systemic inflammatory state, which can cause TL shortening. Thus, the aim of the present review was to show the relationship between obesity and TL in addition to the possible risk factors for its shortening and how the different strategies for weight loss can modulate TL. As the crucial result, we can consider the association between TL and weight loss, and adiposity changes after different interventions, showing that TL may be used as a biomarker of responses to obesity treatment.
端粒是位于染色体末端的结构，与蛋白质相关，来自庇护复合物，负责保护和保存遗传物质。端粒长度（TL）随着每次细胞分裂逐渐缩短，最近的证据表明，生活方式可以导致端粒缩短。在肥胖个体中，过多的脂肪组织在诱导慢性和全身性炎症状态中起着关键作用，这可能导致 TL 缩短。因此，本综述的目的是展示肥胖与 TL 之间的关系，以及 TL 缩短的可能危险因素，以及减肥的不同策略如何调节 TL。作为关键结果，我们可以考虑 TL 与减肥之间的关联，以及不同干预措施后体脂变化，表明 TL 可作为肥胖治疗反应的生物标志物。
