Nicoloso G, Hauert J, Kruithof E K, van Melle G, Bachmann F
Département de médecine, CHUV, Lausanne.
Schweiz Med Wochenschr. 1988 Jan 31;118(4):122-4.
To identify persons at risk for development of thromboembolic disease, fibrinolytic and blood coagulation parameters of normal controls (n = 40) and patients (n = 40) have been compared. Four fibrinolytic parameters, i.e. fibrinolytic activity at rest (FAr), fibrinolytic response after 10 minutes of venous occlusion (delta FA10'), and resting antigenic levels of the plasmatic inhibitor of the plasminogen activators (PAI-1) and of urokinase (u-PA), showed significant differences between the two study groups. The separate and combined discriminant analysis of FAr and delta FA10' values revealed that individuals with FAr below 0.63 UI/ml or a delta FA10' below 0.98 UI/ml are at risk for development of thromboembolic disease.
为了识别有发生血栓栓塞性疾病风险的人群，对40名正常对照者和40名患者的纤溶和凝血参数进行了比较。四个纤溶参数，即静息纤溶活性（FAr）、静脉闭塞10分钟后的纤溶反应（δFA10'）以及纤溶酶原激活物的血浆抑制剂（PAI-1）和尿激酶（u-PA）的静息抗原水平，在两个研究组之间显示出显著差异。对FAr和δFA10'值进行单独和联合判别分析发现，FAr低于0.63 UI/ml或δFA10'低于0.98 UI/ml的个体有发生血栓栓塞性疾病的风险。
