Fong Y, Hesse D G, Tracey K J, Albert J D, Legaspi A, Brennan M F, Lowry S F
Laboratory of Surgical Metabolism, New York Hospital-Cornell Medical Center, NY 10021.
Ann Surg. 1988 Mar;207(3):297-304. doi: 10.1097/00000658-198803000-00012.
The peripheral nitrogen wasting and loss of functional capacity caused by the malnutrition of disease and the immobilization of hospitalization may not be readily reversed by refeeding alone. In order to examine submaximal exercise as an adjunctive anabolic stimulus to intravenous refeeding (IVF) in depleted subjects, 14 volunteers were studied in the postabsorptive (PA) state, after 10 days of total starvation, and again after 10 days of nutritional repletion with I.V. feedings. The subjects were randomized to one group that received IVF alone and one group that performed 1 hour of submaximal (51% of VO2max) stationary bicycle exercise daily during IVF. The exercised group was not significantly different from the nonexercised group in urinary nitrogen balance, resting energy expenditure, extremity amino acid flux, or maximal oxygen consumption. Acute exercise did not induce significant derangements in electrolytes or counter-regulatory hormone concentrations. Ten days of submaximal exercise does not appear to be detrimental in this population recovering from moderate hospitalized malnutrition, but additional anabolic stimulae may be needed for improvements in protein accrual or functional capacity.
疾病导致的营养不良和住院期间的活动受限所引起的外周氮流失和功能能力丧失，可能无法仅通过重新喂食就轻易逆转。为了研究次最大强度运动作为一种辅助合成代谢刺激因素对营养耗竭受试者静脉内重新喂食（IVF）的作用，对14名志愿者在空腹（PA）状态下、完全饥饿10天后以及静脉内喂食营养补充10天后进行了研究。受试者被随机分为一组仅接受IVF，另一组在IVF期间每天进行1小时次最大强度（最大摄氧量的51%）的固定自行车运动。运动组在尿氮平衡、静息能量消耗、肢体氨基酸通量或最大耗氧量方面与非运动组没有显著差异。急性运动并未引起电解质或反调节激素浓度的显著紊乱。对于从中度住院营养不良中恢复的人群，10天的次最大强度运动似乎并无害处，但可能需要额外的合成代谢刺激来改善蛋白质积累或功能能力。
