新生儿期补充铁剂对早期缺铁风险 6 月龄婴儿铁状态的影响：一项随机干预试验。

Effect of iron supplementation from neonatal period on the iron status of6-month-old infants at-risk for early iron deficiency: a randomized interventional trial.

机构信息

Neonatal Unit, Assam Medical College, Dibrugarh, India.

Division of Biostatistics, School of Public Health, University of Minnesota, Minneapolis, MN, USA.

出版信息

J Matern Fetal Neonatal Med. 2021 May;34(9):1421-1429. doi: 10.1080/14767058.2019.1638358. Epub 2019 Jul 9.

DOI:10.1080/14767058.2019.1638358

PMID:31258019

Abstract

OBJECTIVE

To investigate the effects of iron supplementation from the second day after birth on 6-month hemoglobin (Hb), serum ferritin and motor development in infants at risk of early iron deficiency.

STUDY DESIGN

Term (37-41 weeks) infants of anemic (Hb ≤ 100 g L; = 100) and non-anemic (Hb > 100 g L; = 100) mothers were randomized to daily iron supplementation at a dose of 2 mg kg from 36 h of age ( = 50, each of anemic and non-anemic mothers) or no iron-supplementation ( = 50 each of anemic and non-anemic mothers). Hb, serum ferritin and motor development at 6 months were compared in the two groups.

RESULTS

Iron-supplemented infants had higher Hb (103.7 ± 9.3 g L versus 97.0 ± 9.4 g L, < .0001) and serum ferritin (133.93 ± 52.41 ng mL versus 78.09 ± 42.03 ng mL, < .001) concentrations, compared with the no iron-supplementation group. Their motor development was closer to age-appropriate norms than the no iron-supplementation group (5.83 ± 0.69 versus 5.18 ± 1.35, < .01).

CONCLUSION

Early Iron supplementation is effective for improving iron status and motor development at 6 months in infants at risk for early iron deficiency.

摘要

目的

研究出生后第二天开始补铁对有早期缺铁风险的婴儿 6 个月时血红蛋白（Hb）、血清铁蛋白和运动发育的影响。

研究设计

足月（37-41 周）贫血（Hb≤100 g/L；=100）和非贫血（Hb＞100 g/L；=100）母亲的婴儿，随机分为从 36 小时龄开始每天补充 2 mg/kg 铁（=50 名贫血和非贫血母亲各 50 名）或不补铁（=50 名贫血和非贫血母亲各 50 名）。比较两组婴儿在 6 个月时的 Hb、血清铁蛋白和运动发育情况。

结果

与未补铁组相比，补铁组婴儿的 Hb（103.7±9.3 g/L 与 97.0±9.4 g/L，<.0001）和血清铁蛋白（133.93±52.41 ng/mL 与 78.09±42.03 ng/mL，<.001）浓度更高，其运动发育也更接近年龄适宜的标准（5.83±0.69 与 5.18±1.35，<.01）。