9至11个月婴儿缺铁性贫血的患病率及全血细胞计数、网织红细胞参数的参考范围

Prevalence of Iron Deficiency Anemia and Reference Range of Complete Blood Count, Reticulocyte Parameters in Infants Aged 9-11 Months.

作者信息

Ringoringo Harapan Parlindungan

机构信息

Department of Child Health, Faculty of Medicine, Lambung Mangkurat University - RSD Idaman Banjarbaru, Banjarbaru, South Kalimantan, Indonesia.

出版信息

Int J Gen Med. 2022 Nov 2;15:8017-8024. doi: 10.2147/IJGM.S383055. eCollection 2022.

DOI:10.2147/IJGM.S383055

PMID:36348977

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9637362/

Abstract

BACKGROUND

Iron deficiency anemia (IDA) is still a major global health problem. Determination of reference ranges for complete blood count (CBC), reticulocyte hemoglobin content (Ret-He), immature reticulocyte fraction (IRF), and reticulocyte production index (RPI) are essential to help diagnose a disease.

PURPOSE

The study aims to know the prevalence of IDA, risk factors that influence it, and set a reference range for CBC and reticulocyte parameters in infants aged 9-11 months in Indonesia.

PATIENTS AND METHODS

The study was conducted prospectively at 10 Community Health Centers in Banjarbaru, South Kalimantan, Indonesia, from August 2020 to August 2021.

RESULTS

This study recruited 100 healthy infants (47% boys, 53% girls) aged 9-11 months. The prevalence of IDA was 32%. There is no association between IDA prevalence with the mother's education and occupation, maternal parity, family income, and infant nutritional status (p > 0.05). The reference range for hemoglobin (Hb) at P2.5-P97.5, P3-P97, P5-P95 and mean ± 2SD was 11.06 to 14.34 g/dL, 11.10 to 14.31 g/dL, 11.13 to 13.90 g/dL and 10.57 to 13.65 g/dL, respectively. This study also defined the reference ranges for reticulocyte parameters.

CONCLUSION

The reference range of CBC, Ret-He, IRF, and RPI for healthy infants aged 9-11 months in this study can be used as a benchmark.

摘要

背景

缺铁性贫血（IDA）仍是一个重大的全球健康问题。确定全血细胞计数（CBC）、网织红细胞血红蛋白含量（Ret-He）、未成熟网织红细胞比例（IRF）和网织红细胞生成指数（RPI）的参考范围对于帮助诊断疾病至关重要。

目的

本研究旨在了解印度尼西亚9至11个月婴儿缺铁性贫血的患病率、影响其的危险因素，并设定全血细胞计数和网织红细胞参数的参考范围。

患者和方法

该研究于2020年8月至2021年8月在印度尼西亚南加里曼丹省班贾尔baru的10个社区卫生中心进行。

结果

本研究招募了100名9至11个月的健康婴儿（47%为男孩，53%为女孩）。缺铁性贫血的患病率为32%。缺铁性贫血患病率与母亲的教育程度和职业、母亲的胎次、家庭收入以及婴儿的营养状况之间无关联（p>0.05）。血红蛋白（Hb）在P2.5 - P97.5、P3 - P97、P5 - P95以及均值±2标准差时的参考范围分别为11.06至14.34 g/dL、11.10至14.31 g/dL、11.13至13.90 g/dL以及10.57至13.65 g/dL。本研究还确定了网织红细胞参数的参考范围。