The Novel CHADS-VASC-FSH Score is Predictive of Severe Coronary Artery Disease on Coronary Angiography in Patients with Atrial Fibrillation and Unstable Symptoms.

OBJECTIVE

AF may create confusion about the presence of severe or unstable coronary artery disease in cases with unstable symptoms. Novel scores and markers are needed to determine severe coronary artery disease in such patients. We aimed to test the newly developed CHADS-VASc-FSH score, developed by adding family history for coronary artery disease, hyperlipidemia, and smoking to the original CHADS-VASc score, in the prediction of severe CAD in patients with AF and unstable symptoms.

MATERIALS AND METHODS

We retrospectively analyzed 72 patients presenting to Başkent Universtiy School of Medicine Hospital between April 2011 and January 2016. The CHADSVASc-FSH score was assessed for the prediction of severe CAD.

RESULTS

Seventy-two patients aged 65.7±11.2 years were enrolled. Thirty-five (48.6%) patients had severe CAD and 11 (15.3%) had unstable CAD. patients with severe coronary artery disease had a significantly greater CHADSVASC-FSH score (5 (1-8) vs 3(0-7); p<0.05). The CHADSVASC-FSH score independently predicted severe CAD, with a CHADSVASc-FSH score of 3 or greater having a sensitivity of 77.1% and a specificity of 56.8% for severe CAD.

CONCLUSION

Among patients with AF and unstable symptoms, the CHADSVASc-FSH score independently predicts severe CAD.