Sohu Din Muhammad, Sohail Saba, Shaikh Rehana
Dr. Din Muhammad Sohu, MBBS, FCPS-II Resident, Department of Radiology, Dow University of Health Sciences/ Dr. Ruth K. M. Pfau, Civil Hospital, Karachi, Pakistan.
Dr. Saba Sohail, MBBS, MCPS, FCPS, Ph.D, Department of Radiology, Dow University of Health Sciences/ Dr. Ruth K. M. Pfau, Civil Hospital, Karachi, Pakistan.
Pak J Med Sci. 2019;35(3):726-730. doi: 10.12669/pjms.35.3.1011.
To determine the diagnostic accuracy of DWI in differentiating benign and malignant meningiomas keeping histopathology as gold standard.
This was a descriptive analytical study conducted at Radiology Department, DUHS/Dr. Ruth K. M. Pfau Civil Hospital Karachi, from August 2016 to March 2018.It included152 patients clinically suspected of meningioma on conventional neuroimaging. Imaging features of DWI were compared with histopathology findings. The diagnostic accuracy of DWI was calculated in terms of sensitivity, specificity, accuracy, PPV and NPV using histopathology as gold standard.
There were 59 male and 93 female patients with mean age of 55.38±9.8 years. Mean duration of sign and symptoms was 5.67±2.57 months. Out of 152 patients, 117(77%) and 35(23%) were differentiated into benign and malignant meningiomas respectively by DWI while 135(88.82%) and17(11.18%) patients were diagnosed respectively on histopathology. The sensitivity, specificity, PPV, NPV and accuracy of DWI of 84.4%, 82.3%, 97.4%, 40%, and 84.2% respectively keeping histopathology as gold standard.
DWI features along with calculation of ADC values is a reliable non-invasive technique for differentiating benign and malignant meningiomas. However the low negative predictive value necessitates the use of histopathology.
以组织病理学为金标准，确定弥散加权成像（DWI）鉴别良性和恶性脑膜瘤的诊断准确性。
这是一项描述性分析研究，于2016年8月至2018年3月在卡拉奇DUHS/露丝·K·M·普法乌博士市民医院放射科进行。研究纳入了152例临床怀疑患有脑膜瘤的患者，这些患者接受了传统神经影像学检查。将DWI的影像学特征与组织病理学结果进行比较。以组织病理学为金标准，计算DWI的敏感性、特异性、准确性、阳性预测值（PPV）和阴性预测值（NPV），从而得出其诊断准确性。
共有59例男性和93例女性患者，平均年龄为55.38±9.8岁。症状和体征的平均持续时间为5.67±2.57个月。在152例患者中，DWI分别将117例（77%）和35例（23%）鉴别为良性和恶性脑膜瘤，而组织病理学分别诊断出135例（88.82%）和17例（11.18%）患者。以组织病理学为金标准，DWI的敏感性、特异性、PPV、NPV和准确性分别为84.4%、82.3%、97.4%、40%和84.2%。
DWI特征以及表观扩散系数（ADC）值的计算是鉴别良性和恶性脑膜瘤的可靠非侵入性技术。然而，低阴性预测值使得组织病理学检查成为必要。
