Zhang Fang, Wu Anhao, Wang Yinhui, Liu Jianmin
Department of Tumor 2 Families, Central Hospital of Enshi Tujia and Miao Autonomous Prefecture, Enshi, Hubei 445000, P.R. China.
Department of Thoracic Surgery Ward II, Third Affiliated Hospital of Kunming Medical University, Tumor Hospital of Yunnan Province, Kunming, Yunnan 650100, P.R. China.
Exp Ther Med. 2019 Jul;18(1):664-670. doi: 10.3892/etm.2019.7606. Epub 2019 May 23.
Glioma is one of the most common types of malignant cancer and the significance of microRNAs (miRNAs) in cancer therapy has been demonstrated. In the current study, miR-490-3p expression was significantly downregulated in glioma tissue and cell lines. Overexpression of miR-490-3p inhibited glioma cell proliferation and migration . In addition, the high-mobility group AT-hook 2 (HMGA2) was identified as a candidate target gene of miR-490-3p. The current study demonstrated that miR-490-3p mimic could inhibit HMGA2 protein expression in glioma cells. In addition, correlation analysis demonstrated that miR-490-3p and HMGA2 expression was inversely correlated in glioma tissues. Furthermore, the inhibitory effect of miR-490-3p mimic on cell proliferation and migration was partially reversed by the overexpression of HMGA2. Taken together, these results suggest that miR-490-3p may have a tumor suppressive role in glioma and therefore miR-490-3p may be a new target for the treatment of glioma.
神经胶质瘤是最常见的恶性肿瘤类型之一，且微小RNA（miRNA）在癌症治疗中的重要性已得到证实。在当前研究中，miR-490-3p在神经胶质瘤组织和细胞系中的表达显著下调。miR-490-3p的过表达抑制了神经胶质瘤细胞的增殖和迁移。此外，高迁移率族AT钩蛋白2（HMGA2）被确定为miR-490-3p的一个候选靶基因。当前研究表明，miR-490-3p模拟物可抑制神经胶质瘤细胞中HMGA2蛋白的表达。此外，相关性分析表明，在神经胶质瘤组织中miR-490-3p与HMGA2的表达呈负相关。此外，HMGA2的过表达部分逆转了miR-490-3p模拟物对细胞增殖和迁移的抑制作用。综上所述，这些结果表明miR-490-3p在神经胶质瘤中可能具有肿瘤抑制作用，因此miR-490-3p可能是神经胶质瘤治疗的一个新靶点。
