Chon Hye Sook, Sehovic Marina, Marchion Douglas, Walko Christine, Xiong Yin, Extermann Martine
Department of Gynecology Oncology, Moffitt Cancer Center and Research Institute, Tampa FL, USA.
University of South Florida, Tampa FL, USA.
J Cancer. 2019 Jun 2;10(12):2604-2618. doi: 10.7150/jca.29611. eCollection 2019.
The increase of both life expectancy of the Western industrialized population and cancer incidence with aging is expected to result in a rapid expansion of the elderly cancer population, including patients with epithelial ovarian cancer (EOC). Although the survival of patients with EOC has generally improved over the past three decades, this progress has yet to provide benefits for elderly patients. Compared with young age, advanced age has been reported as an adverse prognostic factor influencing EOC. However, contradicting results have been obtained, and the mechanisms underlying this observation are poorly defined. Few papers have been published on the underlying biological mechanisms that might explain this prognosis trend. We provide an extensive review of mechanisms that have been linked to EOC prognosis and/or aging in the published literature and might underlie this relationship in humans.
西方工业化国家人口预期寿命的增加以及癌症发病率随年龄增长而上升，预计将导致老年癌症患者群体迅速扩大，其中包括上皮性卵巢癌（EOC）患者。尽管在过去三十年中，EOC患者的生存率总体上有所提高，但这一进展尚未给老年患者带来益处。与年轻患者相比，高龄已被报道为影响EOC的不良预后因素。然而，研究结果相互矛盾，且这一现象背后的机制尚不明确。关于可能解释这种预后趋势的潜在生物学机制的论文发表较少。我们对已发表文献中与EOC预后和/或衰老相关且可能是人类这种关系基础的机制进行了全面综述。
