Ciobica A, Balmus I M, Padurariu M
"Alexandru Ioan Cuza" University, Iaşi, Romania.
Center of Biomedical Research of the Romanian Academy, Iaşi Branch, Iaşi, Romania.
Acta Endocrinol (Buchar). 2016 Jan-Mar;12(1):65-71. doi: 10.4183/aeb.2016.65.
Oxytocin is a complex molecule involved in a variety of biological processes at both the central and the peripheral level. Although its role was initially associated almost exclusively with birth and breastfeeding, recent studies are suggesting that in fact oxytocin could be involved in many other physiological and pathological processes. In this way, lately there is a growing interest towards a possible involvement of oxytocin in many etiopathogenic and psychopathological processes, as for example in the affective disorders, where the roles of oxytocin are not yet clearly understood. In this paper we shortly describe the main aspects regarding the relevance of oxytocin administration or its mechanisms in the affective disorders, as well as its relations with the hypothalamic-pituitary-adrenal axis and cortisol secretion. It seems that although the researches on the importance of oxytocin in the affective disorders are rather at the beginning, an increasing number of evidence is supporting the involvement of oxytocin in the pathogenic processes of these psychiatric disorders. Still, the studies covering this topic are still in their early days, and the results that are trying to understand if there is a major role of oxytocin in affective disorders are not consistent enough to draw definitive conclusions and establish with certainty where the place of oxytocin in the affective disorders pathology is.
催产素是一种复杂的分子，在中枢和外周水平参与多种生物过程。尽管其作用最初几乎完全与分娩和母乳喂养相关，但最近的研究表明，事实上催产素可能参与许多其他生理和病理过程。这样一来，近来人们越来越关注催产素可能参与许多病因和精神病理过程，例如情感障碍，而催产素在其中的作用尚未明确。在本文中，我们简要描述了关于催产素给药或其机制在情感障碍中的相关性的主要方面，以及它与下丘脑 - 垂体 - 肾上腺轴和皮质醇分泌的关系。似乎尽管关于催产素在情感障碍中的重要性的研究尚处于起步阶段，但越来越多的证据支持催产素参与这些精神疾病的致病过程。然而，涵盖该主题的研究仍处于早期阶段，试图了解催产素在情感障碍中是否起主要作用的结果并不足够一致，无法得出明确结论并确定催产素在情感障碍病理学中的位置。
