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On the low reproducibility of cancer studies.

作者信息

Wen Haijun, Wang Hurng-Yi, He Xionglei, Wu Chung-I

机构信息

State Key Laboratory of Biocontrol, College of Ecology and Evolution, Sun Yat-Sen University, Guangzhou.

Graduate Institute of Clinical Medicine and Hepatitis Research Center, Taiwan University and Hospital, Taipei.

出版信息

Natl Sci Rev. 2018 Sep;5(5):619-624. doi: 10.1093/nsr/nwy021. Epub 2018 Feb 2.

DOI:10.1093/nsr/nwy021
PMID:31258951
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6599599/
Abstract
摘要

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本文引用的文献

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Natl Sci Rev. 2017 Sep;4(5):721-734. doi: 10.1093/nsr/nwx065. Epub 2017 Jun 5.
2
Replication Study: Transcriptional amplification in tumor cells with elevated c-Myc.复制研究:高表达 c-Myc 的肿瘤细胞中的转录扩增。
Elife. 2018 Jan 9;7:e30274. doi: 10.7554/eLife.30274.
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Replication Study: Systematic identification of genomic markers of drug sensitivity in cancer cells.复制研究:系统鉴定癌细胞药物敏感性的基因组标记物。
Elife. 2018 Jan 9;7:e29747. doi: 10.7554/eLife.29747.
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Replication Study: Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemia.复制研究:抑制BET蛋白与染色质的结合作为治疗MLL融合白血病的有效方法。
Elife. 2017 Jun 27;6:e25306. doi: 10.7554/eLife.25306.
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A mathematical theory of the transcription repression (TR) therapy of cancer - whether and how it may work.癌症转录抑制(TR)疗法的数学理论——它是否可行以及如何发挥作用。
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Implications of cancer evolution for drug development.癌症进化对药物研发的影响。
Nat Rev Drug Discov. 2017 Jul;16(7):441-442. doi: 10.1038/nrd.2017.78. Epub 2017 Apr 28.
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Cancer reproducibility project releases first results.癌症可重复性项目公布首批结果。
Nature. 2017 Jan 18;541(7637):269-270. doi: 10.1038/541269a.
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Mixed outcomes for computational predictions.计算预测结果不一。
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Making sense of replications.理解重复实验结果。
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