Mao Yu, Ye Fei, Jiang Qin, Liu Sushun, Gong Yi
Department of Thyroid Surgery, the Second Xiangya Hospital, Central South University, Changsha, P.R. China.
Medicine (Baltimore). 2025 Mar 14;104(11):e41835. doi: 10.1097/MD.0000000000041835.
This study aims to analyze and identify primary research trends in targeted therapy for thyroid carcinoma (TC). It seeks to provide a factual foundation for researchers, as TC often presents with advanced stages and aggressive subtypes, leading to unfavorable clinical outcomes. The evolution of targeted therapies introduces promising treatment possibilities, necessitating a bibliometric analysis to better understand the current state and trends in this field. A comprehensive bibliometric analysis was conducted using data from the Web of Science Core Collection (WOSCC). Advanced search queries established a literature database, and the analysis was performed using tools such as VOSviewer, CiteSpace, Tableau, and Microsoft Excel. The study focused on publications from 2013 to 2023, examining patterns, geographical contributions, institutional output, and influential journals. The analysis identified 763 publications on TC targeted therapy during the study period, with significant contributions from the United States, China, and Italy, and the United States leading in output. Research activity peaked in 2021, showing overall fluctuating growth. Key contributing institutions included the University of Texas MD Anderson Cancer Center and the University of Pisa. Notable journals, such as Cancers and Thyroid, were among the most cited, underscoring their impact in the field. The study highlighted an increase in global research output and robust international collaborations, particularly among the leading contributing countries. This bibliometric analysis provides a comprehensive overview of significant contributions and trends in targeted therapy research for TC. It identifies key development processes and research hotspots, offering valuable insights to guide future research directions. The findings aim to stimulate further studies and foster advancements in this critical area of oncology.
本研究旨在分析和确定甲状腺癌（TC）靶向治疗的主要研究趋势。由于甲状腺癌常呈现晚期阶段和侵袭性亚型，导致临床预后不佳，本研究旨在为研究人员提供事实依据。靶向治疗的发展带来了有前景的治疗可能性，因此需要进行文献计量分析，以更好地了解该领域的现状和趋势。使用来自科学网核心合集（WOSCC）的数据进行了全面的文献计量分析。通过高级搜索查询建立了文献数据库，并使用VOSviewer、CiteSpace、Tableau和Microsoft Excel等工具进行分析。该研究聚焦于2013年至2023年的出版物，考察了研究模式、地理贡献、机构产出和有影响力的期刊。分析确定在研究期间有763篇关于TC靶向治疗的出版物，美国、中国和意大利贡献显著，美国的产出领先。研究活动在2021年达到峰值，总体呈波动增长。主要贡献机构包括德克萨斯大学MD安德森癌症中心和比萨大学。诸如《Cancers》和《Thyroid》等著名期刊被引用次数最多，突显了它们在该领域的影响力。该研究强调全球研究产出增加以及强大的国际合作，特别是在主要贡献国家之间。这项文献计量分析全面概述了TC靶向治疗研究的重大贡献和趋势。它确定了关键的发展过程和研究热点，为指导未来研究方向提供了有价值的见解。研究结果旨在激发进一步的研究，并促进肿瘤学这一关键领域的进展。
