Greenblatt Rebecca E, Himes Blanca E
Department of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.
AMIA Jt Summits Transl Sci Proc. 2019 May 6;2019:553-561. eCollection 2019.
Exposure to pollutants impacts health and has been associated with a range of diseases, including respiratory and heart diseases, as well as all-cause mortality. Because taking exposure measures for individual studies is costly and impractical, most rely on data from sources such as the Environmental Protection Agency (EPA), which provides a wealth of publicly available pollution measures taken at over two thousand monitoring sites across the United States. While EPA data is readily available, estimating pollution exposure at a given latitude-longitude location remains computationally intensive. We developed Pollution-Associated Risk Geospatial Analysis SITE (PARGASITE), an online web-application and R package, that can be used to estimate levels of pollutants in the U.S. for 2005 through 2017 at user-defined geographic locations and time ranges. We demonstrate how PARGASITE can facilitate the study of associations between exposures and health outcomes using as an example an analysis of asthma risk factors among adults.
接触污染物会影响健康，并与一系列疾病相关联，包括呼吸道疾病和心脏病，以及全因死亡率。由于为个体研究采取接触测量措施成本高昂且不切实际，大多数研究依赖于来自环境保护局（EPA）等来源的数据，该机构提供了在美国两千多个监测站点采集的大量可公开获取的污染测量数据。虽然EPA数据很容易获取，但在给定经纬度位置估算污染暴露量在计算上仍然很密集。我们开发了污染相关风险地理空间分析站点（PARGASITE），这是一个在线网络应用程序和R包，可用于在用户定义的地理位置和时间范围内估算2005年至2017年美国的污染物水平。我们以对成年人哮喘风险因素的分析为例，展示了PARGASITE如何促进对接触与健康结果之间关联的研究。
