在腹部近红外光谱血氧测定法中，需要考虑早产儿早期粪便的吸收光谱。
Absorption spectra of early stool from preterm infants need to be considered in abdominal NIRS oximetry.
作者信息
Isler Helene, Schenk Daniel, Bernhard Jérôme, Kleiser Stefan, Scholkmann Felix, Ostojic Daniel, Kalyanov Alexander, Ahnen Linda, Wolf Martin, Karen Tanja
机构信息
Biomedical Optics Research Laboratory, Department of Neonatology, University Hospital Zürich, 8091 Zürich, Switzerland.
CARAG AG, 6340 Baar, Switzerland.
出版信息
Biomed Opt Express. 2019 May 15;10(6):2784-2794. doi: 10.1364/BOE.10.002784. eCollection 2019 Jun 1.
Necrotizing enterocolitis (NEC) is the most common gastrointestinal emergency of the preterm infant. Low abdominal tissue oxygen saturation (StO) measured by near-infrared spectroscopy (NIRS) oximetry may be an early sign of NEC relevant for treating or even preventing NEC. However, current commercial NIRS oximeters provide inaccurate StO readings because they neglect stool as an abdominal absorber. To tackle this problem, we determined the optical properties of faeces of preterm infants to enable a correct abdominal StO measurement. In 25 preterm born infants (median age 31 0/7 ± 2 1/7 weeks, weight 1478 ± 511 g), we measured their first five stool probes with a VIS/NIR spectrometer and calculated the optical properties using the Inverse Adding Doubling (IAD) method. We obtained two absorption spectra representing and . Probabilistic cluster analysis correctly classified 96 out of 107 stool probes. The faeces spectra need to be considered to enable correct abdominal StO measurements with NIRS oximetry.
坏死性小肠结肠炎（NEC）是早产儿最常见的胃肠道急症。通过近红外光谱（NIRS）血氧测定法测量的下腹部组织氧饱和度（StO）可能是与NEC治疗甚至预防相关的早期迹象。然而，目前的商用NIRS血氧计提供的StO读数不准确，因为它们忽略了粪便作为腹部吸收体的影响。为了解决这个问题，我们测定了早产儿粪便的光学特性，以便能够正确测量腹部StO。在25例早产婴儿（中位年龄31又0/7±2又1/7周，体重1478±511克）中，我们用可见/近红外光谱仪测量了他们的前五次粪便样本，并使用反向加倍法（IAD）计算了光学特性。我们获得了代表……和……的两个吸收光谱。概率聚类分析正确分类了107个粪便样本中的96个。需要考虑粪便光谱，以便通过NIRS血氧测定法正确测量腹部StO。 （注：原文中“representing and.”部分内容缺失，翻译时保留原文状态）
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