颅骨厚度对新生儿脑近红外光谱血氧测定的影响：一项计算机模拟研究。
Impact of Skull Thickness on Cerebral NIRS Oximetry in Neonates: An in silico Study.
机构信息
Biomedical Optics Research Laboratory (BORL), Department of Neonatology, University Hospital Zurich, University of Zurich, Zurich, Switzerland.
出版信息
Adv Exp Med Biol. 2020;1232:33-38. doi: 10.1007/978-3-030-34461-0_5.
Monitoring of cerebral tissue oxygen saturation (StO) by near-infrared spectroscopy (NIRS oximetry) has great potential to reduce the incidence of hypoxic and hyperoxic events and thus prevent long-term disabilities in preterm neonates. Since the light has to penetrate superficial layers (bone, skin and cerebrospinal fluid) before it reaches the brain, the question arises whether these layers influence cerebral StO measurement. We assessed this influence on the accuracy of cerebral StO values. For that purpose, we simulated light propagation with 'N-layered medium' software. It was found that with a superficial layer thickness of ≤6 mm, typical for term and preterm neonates, StO accurately reflects cerebral tissue oxygenation.
近红外光谱（NIRS 血氧测定）监测脑组织氧饱和度（StO）具有降低早产儿缺氧和高氧事件发生率的巨大潜力，从而预防长期残疾。由于光在到达大脑之前必须穿透浅层（骨骼、皮肤和脑脊液），因此出现了一个问题，即这些层是否会影响大脑 StO 测量。我们评估了这种对大脑 StO 值准确性的影响。为此，我们使用“N 层介质”软件模拟了光的传播。结果发现，对于典型的足月和早产儿，当浅层厚度≤6mm 时，StO 能准确反映脑组织氧合情况。
Zotero 插件