Yakovlev Evgeny, Shandybina Galina, Shamova Alexandra
Saint Petersburg National Research University of Information Technologies, Mechanics and Optics, 49 Kronverksky Ave, Saint Petersburg, 197101, Russia.
Biomed Opt Express. 2019 May 28;10(6):3030-3040. doi: 10.1364/BOE.10.003030. eCollection 2019 Jun 1.
An analytical model is presented that qualitatively describes the cooling of a biological tissue after irradiation with short and ultrashort laser pulses. The assumption that the distribution of temperature at the initial moment of surface cooling repeats the distribution of the absorbed laser energy allowed us to use the thermal conductivity approximation in both cases. The experimental results of irradiation of dry bone with nanosecond and femtosecond laser pulses are compared with the calculated data. The necessity of taking into account the change in the optical parameters of hard tissue in the field of laser irradiation during its treatment by nanosecond and femtosecond laser pulses and the key role of residual heating in its carbonization around the exposure region is shown. The application of the model to a particular biological tissue can significantly simplify the search for optimal parameters of lasers for surgical procedures.
提出了一种分析模型，该模型定性地描述了生物组织在受到短脉冲和超短激光脉冲照射后的冷却过程。表面冷却初始时刻温度分布重复吸收激光能量分布这一假设，使我们在两种情况下都能使用热导率近似。将纳秒和飞秒激光脉冲照射干骨的实验结果与计算数据进行了比较。结果表明，在纳秒和飞秒激光脉冲治疗硬组织过程中，考虑激光照射区域内硬组织光学参数变化的必要性，以及残余加热在暴露区域周围碳化过程中的关键作用。将该模型应用于特定生物组织可显著简化手术过程中激光最佳参数的寻找。
