通过血清氢核磁共振波谱法研究肥胖对年轻成年人脂质和代谢物谱的影响。
Effects of obesity on the lipid and metabolite profiles of young adults by serum H-NMR spectroscopy.
作者信息
Pasanta Duanghathai, Chancharunee Sirirat, Tungjai Montree, Kim Hong Joo, Kothan Suchart
机构信息
Department of Radiologic Technology, Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai, Thailand.
Department of Chemistry, Faculty of Science, Chiang Mai University, Chiang Mai, Thailand.
出版信息
PeerJ. 2019 Jun 20;7:e7137. doi: 10.7717/peerj.7137. eCollection 2019.
BACKGROUND
Overweight (OW) is considered a risk for various metabolic diseases. However, its effects as a mechanism that alters the metabolite profiles remain unclear. The purpose of this study is to investigate the effects that OW has on the lipid and metabolite profiles in young adults.
METHODS
The serum metabolite profiles of 46 young adults of normal weight and those considered OW were studied by Proton nuclear magnetic resonance spectroscopy (H NMR) technique.
RESULTS
H NMR metabolite analysis shows the alteration of metabolic levels and increased levels of CH lipids and CH lipids, which are used as unique biomarkers to identify OW subjects from the normal weight groups.
CONCLUSION
This present study reveals that OW contributes to the systemic metabolism and the metabolite alteration among young adults. The alteration in serum lipids level could shed the light on metabolic syndrome pathogenesis in young adults and needs further elucidation.
背景
超重被认为是多种代谢性疾病的风险因素。然而，其作为改变代谢物谱的一种机制的作用仍不清楚。本研究的目的是调查超重对年轻人脂质和代谢物谱的影响。
方法
采用质子核磁共振波谱（H NMR）技术研究了46名正常体重和超重年轻人的血清代谢物谱。
结果
H NMR代谢物分析显示代谢水平发生改变，胆固醇（CH）脂质和甘油三酯水平升高，这些被用作从正常体重组中识别超重受试者的独特生物标志物。
结论
本研究表明超重会影响年轻人的全身代谢和代谢物改变。血清脂质水平的改变可能为年轻人代谢综合征的发病机制提供线索，需要进一步阐明。
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