Laks H, Kaiser G C, Mudd J G, Halstead J, Pennington G, Tyras D, Codd J, Barner H B
Am J Cardiol. 1979 Jun;43(6):1109-13. doi: 10.1016/0002-9149(79)90141-3.
This study was undertaken to evaluate revascularization of the right coronary artery with regard to factors that enter into the decision to graft less significant lesions, such as graft flow, graft patency and progression of proximal disease. The results of grafting the right coronary artery were studied in 23 patients with lesions reducing luminal diameter by less than 50 percent (Group 1), 35 patients with luminal narrowing of 50 to 70 percent (Group 2) and 112 patients with greater than 70 percent luminal narrowing (Group 3). At operation there was no significant difference in saphenous vein graft flows among the three groups. Postoperatively the mean follow-up period was 20, 27 and 26 months, respectively. Graft patency was not significantly different among the three groups. Progression of the proximal lesion was studied and compared with that in 71 ungrafted right coronary arteries, 60 with less than 50 percent stenosis and 11 with more than 50 percent stenosis. Among vessels with less than 50 percent narrowing, the proximal lesion showed progression in 26 percent of the ungrafted vessels and in 83 percent of the grafted vessels (P less than 0.005); progression to total occlusion occurred in 3 percent of the former and in 28 percent of the latter (P less than 0.005). Progression to total occlusion was more frequently associated with a patent than with an occluded graft (P less than 0.05). The occurrence of significant progression in ungrafted vessels and the lack of effect on graft patency of the severity of the proximal disease suggest that revascularization of less significant lesions may be of value. However, the resultant increase in progression of proximal disease makes the patient dependent on the long-term patency of the vein graft.
本研究旨在评估右冠状动脉血运重建情况,涉及影响决定移植意义较小病变的因素,如移植血管血流、移植血管通畅率以及近端病变进展情况。对23例管腔直径缩小小于50%的病变患者(第1组)、35例管腔狭窄50%至70%的患者(第2组)和112例管腔狭窄大于70%的患者(第3组)的右冠状动脉移植结果进行了研究。手术时,三组患者的大隐静脉移植血管血流无显著差异。术后平均随访期分别为20、27和26个月。三组患者的移植血管通畅率无显著差异。对近端病变进展情况进行了研究,并与71条未移植的右冠状动脉进行了比较,其中60条狭窄小于50%,11条狭窄大于50%。在狭窄小于50%的血管中,未移植血管的近端病变进展率为26%,移植血管为83%(P<0.005);进展为完全闭塞的情况,前者为3%,后者为28%(P<0.005)。进展为完全闭塞与移植血管通畅的相关性高于闭塞的移植血管(P<0.05)。未移植血管中显著进展的发生以及近端病变严重程度对移植血管通畅率无影响,提示对意义较小的病变进行血运重建可能具有价值。然而,由此导致的近端病变进展增加使患者依赖于静脉移植血管的长期通畅。