Adamson I, Esangbedo A, Abiodun P
Department of Biochemistry, University of Benin, Nigeria.
Enzyme. 1988;39(1):44-9. doi: 10.1159/000469092.
This study reports on basal gastric pepsins in 40 normal, kwashiorkor and marasmic children admitted to the paediatric wards of the University of Benin Teaching Hospital, Nigeria. The activity of total pepsin was significantly depressed in the diseased states. The various fractions of pepsin separated on ion-exchange chromatography also showed dramatic reductions for both kwashiorkor and marasmus. This adaptive reduction of pepsin and its fractions was more drastic in marasmus than kwashiorkor. On disc-gel electrophoresis, four of the pepsin bands found in normal gastric aspirate were missing in children with the syndromes. Gastric electrolytes and acidity recorded for the diseased states were not conducive for maximal peptic activity. It is suggested that due to the reduced proteolytic capability of the malnourished infants, rehabilitation with intact protein should be cautious and gradual.
本研究报告了尼日利亚贝宁大学教学医院儿科病房收治的40名正常儿童、夸休可尔症儿童和消瘦症儿童的基础胃蛋白酶情况。在患病状态下，总胃蛋白酶活性显著降低。通过离子交换色谱法分离的胃蛋白酶各组分在夸休可尔症和消瘦症患儿中也均显著减少。消瘦症患儿胃蛋白酶及其组分的这种适应性减少比夸休可尔症患儿更为显著。在圆盘凝胶电泳中，患有这些综合征的儿童胃吸出物中发现的四条胃蛋白酶带缺失。患病状态下记录的胃电解质和酸度不利于最大程度的消化活性。建议由于营养不良婴儿的蛋白水解能力降低，以完整蛋白质进行康复治疗时应谨慎且循序渐进。
