Department of Ophthalmology & Roski Eye Institute, Keck School of Medicine, Los Angeles, CA 90033-6103, USA.
Department of Pharmacology & Pharmaceutical Sciences, School of Pharmacy, Los Angeles, CA 90033-6103, USA.
Biomark Med. 2019 Aug;13(11):941-952. doi: 10.2217/bmm-2019-0167. Epub 2019 Jul 2.
Secretion of proteins into basal tears of Parkinson's disease (PD) patients may be altered by changes in nerve function. Oligomeric α-Syn and total α-Syn, CCL-2, DJ-1, LF and MMP-9 were measured in basal tears from 93 PD patients and 82 age- and sex-equivalent healthy controls. α-Syn was decreased (p = 0.0043), whereas α-Syn (p < 0.0001) and the ratio of α-Syn/α-Syn (p < 0.0001) were increased in basal tears from PD patients compared with healthy controls. Area under receiver-operating curves of α-Syn and α-Syn/α-Syn contents were 0.70 (95% confidence limits: 0.621-0.774) and 0.72 (95% confidence limits: 0.642-0.792). PD patient basal tears may contain biomarkers that can be assayed noninvasively and inexpensively.
帕金森病 (PD) 患者基础泪液中的蛋白质分泌可能会因神经功能的改变而发生变化。在 93 名 PD 患者和 82 名年龄和性别匹配的健康对照者的基础泪液中测量了寡聚 α-Syn 和总 α-Syn、CCL-2、DJ-1、LF 和 MMP-9。与健康对照组相比，PD 患者基础泪液中的 α-Syn 减少（p=0.0043），而 α-Syn（p<0.0001）和 α-Syn/α-Syn 比值（p<0.0001）增加。α-Syn 和 α-Syn/α-Syn 含量的受试者工作特征曲线下面积分别为 0.70（95%置信区间：0.621-0.774）和 0.72（95%置信区间：0.642-0.792）。PD 患者的基础泪液可能含有可进行非侵入性和廉价检测的生物标志物。
