Eriksson E, Modigh K, Jansson J O
Department of Pharmacology, University of Göteborg, Sweden.
J Neural Transm. 1988;71(2):99-113. doi: 10.1007/BF01245252.
Administration of reserpine in a dose causing depletion of brain monoamines led to a complete suppression of the pulsatile secretory pattern of growth hormone (GH) in gonadectomized (GX) as well as in sham-operated male and female rats. In GX animals of both sexes treated with estradiol, but not in those treated with testosterone or dihydrotestosterone (DHT), the reserpine induced inhibition of GH release was partially antagonized. Administration of the alpha 2-adrenoceptor agonist clonidine caused secretion of GH in reserpine pretreated, sham-operated rats. In GX male rats GH responses to clonidine were blunted, while in GX males treated with testosterone or estradiol, but not in those treated with DHT, the responses were restored. In female rats gonadectomy did not significantly affect the GH releasing effect of clonidine. However, administration of estradiol to GX females led to enhanced responses to the alpha 2-agonist. Administration of the GH releasing hormone (GHRH) induced pronounced GH secretion in reserpine pretreated animals of both sexes; this effect was not significantly affected by gonadectomy. In GX males, however, GH responses to GHRH were enhanced by replacement with estradiol or testosterone, while in GX females, estradiol, but not testosterone, had the same effect.
给予能导致脑单胺耗竭剂量的利血平，会使去性腺（GX）以及假手术的雄性和雌性大鼠生长激素（GH）的脉冲式分泌模式完全受到抑制。在接受雌二醇治疗的两性GX动物中，利血平诱导的GH释放抑制得到部分拮抗，但在接受睾酮或二氢睾酮（DHT）治疗的动物中则未出现这种情况。给予α2 -肾上腺素能受体激动剂可乐定，可使预先用利血平处理的假手术大鼠分泌GH。在GX雄性大鼠中，对可乐定的GH反应减弱，而在接受睾酮或雌二醇治疗的GX雄性大鼠中，反应恢复，但在接受DHT治疗的大鼠中未恢复。在雌性大鼠中，去性腺对可乐定的GH释放作用没有显著影响。然而，给GX雌性大鼠注射雌二醇会导致对α2 -激动剂的反应增强。给予生长激素释放激素（GHRH）可使预先用利血平处理的两性动物分泌大量GH；这种作用不受去性腺的显著影响。然而，在GX雄性大鼠中，用雌二醇或睾酮替代可增强对GHRH的GH反应，而在GX雌性大鼠中，雌二醇而非睾酮有同样的作用。
