Checkley S A, Slade A P, Shur E
Br J Psychiatry. 1981 Jan;138:51-5. doi: 10.1192/bjp.138.1.51.
The growth hormone response to clonidine was significantly less in 10 drug-free patients with endogenous depression than in 10 normal subjects who were individually matched with the patients for age and sex. The hypotensive and sedative effects of clonidine in the two groups were similar. The findings may indicate a defect at central alpha adrenoceptors at least in neuro-endocrine systems.
10名无药物治疗的内源性抑郁症患者对可乐定的生长激素反应明显低于10名在年龄和性别上与患者个体匹配的正常受试者。可乐定在两组中的降压和镇静作用相似。这些发现可能表明至少在神经内分泌系统中存在中枢α肾上腺素能受体缺陷。
