Fujimoto S, Ohta M, Shrestha R D, Kokubun M, Kobayashi K, Miyoshi T, Arimizu N, Mori T, Okui K
1st Dept. of Surgery, School of Med., Chiba Univ.
Gan No Rinsho. 1988 Feb;34(2):179-82.
Combined chemotherapy for human gastric cancer Transplanted into nude mice has been performed to determine whether misonidazole (MIS) and metronidazole (MTR), derivatives of nitroimidazole, would enhance the antitumor activity of MMC. MTR, 500 mg/kg, MIS 500 mg/kg, and MMC 2.0 mg/kg were administered ip twice during a 48-hour interval. The antitumor efficacies of MMC only, MTR only, or MIS only were seen to be much the same as in the controls. The combined treatment with MMC and MTR surpassed the controls in antitumoral activity after the 12th day, whereas it did not surpass a regimen with MMC alone. The addition of MIS to MMC showed an enhanced antitumoral activity after the 10th day compared to the controls and, further, after the 10th day it exceeded the results of MMC only. Tumor tripling time in cases of MMC only, MTR only, MIS only, MMC plus MTR, and MMC plus MIS was 123, 132, 144, 144, and 178 hours, respectively, compared to 110 hours in the controls. Thus, these results suggest that MIS has a chemosensitizing activity under these conditions, while MTR has little activity.
已对移植到裸鼠体内的人类胃癌进行联合化疗，以确定硝唑咪（MIS）和甲硝唑（MTR）这两种硝基咪唑衍生物是否会增强丝裂霉素（MMC）的抗肿瘤活性。在48小时的间隔内，腹腔注射两次MTR（500mg/kg）、MIS（500mg/kg）和MMC（2.0mg/kg）。单独使用MMC、单独使用MTR或单独使用MIS的抗肿瘤效果与对照组大致相同。MMC与MTR联合治疗在第12天后的抗肿瘤活性超过了对照组，但未超过单独使用MMC的治疗方案。与对照组相比，MMC添加MIS在第10天后显示出增强的抗肿瘤活性，并且在第10天后超过了仅使用MMC的结果。仅使用MMC、仅使用MTR、仅使用MIS、MMC加MTR以及MMC加MIS的肿瘤倍增时间分别为123、132、144、144和178小时，而对照组为110小时。因此，这些结果表明，在这些条件下MIS具有化学增敏活性，而MTR几乎没有活性。
