Tian Yanjun, Wang Shuai, Jiao Fengjuan, Kong Qingsheng, Liu Chuanxin, Wu Yili
Collaborative Innovation Center for Birth Defect Research and Transformation of Shandong Province, Jining Medical University, Jining, China.
Shandong Collaborative Innovation Center for Diagnosis, Treatment and Behavioral Interventions of Mental Disorders, Institute of Mental Health, Jining Medical University, Jining, China.
Front Neurol. 2019 Jun 13;10:624. doi: 10.3389/fneur.2019.00624. eCollection 2019.
Stroke is one of the leading causes of death and disability worldwide. Age is associated with increased risk of stroke, while telomere length shortening plays a pivotal role in the process of aging. Moreover, telomere length shortening is associated with many risk factors of stroke in addition to age. Accumulated evidence shows that short leukocyte telomere length is not only associated with stroke occurrence but also associated with post-stroke recovery in the elderly population. In this review, we aimed to summarize the association between leukocyte telomere length and stroke, and discuss that telomere length might serve as a potential biomarker to predict the risk and prognosis of stroke.
中风是全球主要的死亡和致残原因之一。年龄与中风风险增加相关，而端粒长度缩短在衰老过程中起关键作用。此外，除年龄外，端粒长度缩短还与中风的许多风险因素相关。越来越多的证据表明，白细胞端粒长度缩短不仅与中风发生有关，还与老年人群中风后的恢复有关。在本综述中，我们旨在总结白细胞端粒长度与中风之间的关联，并讨论端粒长度可能作为预测中风风险和预后的潜在生物标志物。
