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如何解决中断治疗缓解期研究中 HIV 传播的风险：低挂果实方法。

How to Address the Risk of HIV Transmission in Remission Studies With Treatment Interruption: The Low-Hanging Fruit Approach.

机构信息

Center for Population-Level Bioethics, Rutgers University, New Brunswick, New Jersey.

出版信息

J Infect Dis. 2019 Jul 2;220(220 Suppl 1):S7-S11. doi: 10.1093/infdis/jiz163.

DOI:10.1093/infdis/jiz163
PMID:31264692
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6603962/
Abstract

Some HIV remission studies include a treatment interruption that seriously risks infecting participants' sex partners with HIV. What, ethically, is owed to these nonparticipants? Until greater certainty emerges on what protections should be afforded nonparticipants of research studies, what I call a "low-hanging fruit" approach may help researchers and review bodies determine how to address infection risks to nonparticipants in these studies.

摘要

一些 HIV 缓解研究包括治疗中断，这严重危及研究参与者的性伴侣感染 HIV 的风险。从伦理上讲，应该给予这些非参与者什么？在研究非参与者应得到何种保护方面，尚未有更大的确定性之前，我所说的“低挂果实”方法可能有助于研究人员和审查机构确定如何应对这些研究中非参与者的感染风险。

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本文引用的文献

1
How Unavoidable Are Analytical Treatment Interruptions in HIV Cure-Related Studies?在 HIV 治愈相关研究中，分析治疗中断的情况有多不可避免？
J Infect Dis. 2019 Jul 2;220(220 Suppl 1):S24-S26. doi: 10.1093/infdis/jiz222.
2
Removing One Barrier to Protecting Sex Partners in HIV Remission Studies With a Treatment Interruption.消除 HIV 缓解研究中断治疗时保护性伴侣的一个障碍。
J Infect Dis. 2019 Jul 2;220(220 Suppl 1):S22-S23. doi: 10.1093/infdis/jiz162.
3
Is it ethical to isolate study participants to prevent HIV transmission during trials with an analytical treatment interruption?在分析性治疗中断试验中，为了防止艾滋病毒传播而将研究参与者隔离开来，这样做是否合乎伦理？
J Infect Dis. 2019 Jul 2;220(220 Suppl 1):S19-S21. doi: 10.1093/infdis/jiz164.
4
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J Infect Dis. 2019 Jul 2;220(220 Suppl 1):S1-S4. doi: 10.1093/infdis/jiz173.
5
Recommendations for analytical antiretroviral treatment interruptions in HIV research trials-report of a consensus meeting.抗逆转录病毒治疗中断分析在 HIV 研究试验中的建议——共识会议报告。
Lancet HIV. 2019 Apr;6(4):e259-e268. doi: 10.1016/S2352-3018(19)30052-9. Epub 2019 Mar 15.
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