De Marco C, Cini C, Blarzino C, Busiello V, Di Girolamo M
Dipartimento di Scienze Biochimiche dell'Università di Roma La Sapienza, Italy.
Physiol Chem Phys Med NMR. 1987;19(3):153-7.
CHO cells allowed to grow in a medium containing selenalysine can utilize it for protein synthesis. Selenalysine is incorporated into cell proteins in substitution of lysine: a maximum of 5% of protein lysine can be substituted. Protein lysine substitution by selenalysine can be correlated to the reduced viability of cells grown in its presence.
允许在中国仓鼠卵巢细胞(CHO)在含有硒代赖氨酸的培养基中生长时,它们能够利用硒代赖氨酸进行蛋白质合成。硒代赖氨酸会取代赖氨酸掺入细胞蛋白质中:蛋白质赖氨酸的最大取代量可达5%。硒代赖氨酸对蛋白质赖氨酸的取代与在其存在下生长的细胞活力降低有关。