锂盐维持治疗对双相情感障碍男性下丘脑-垂体-性腺轴的影响。
Effect of lithium maintenance treatment on hypothalamic pituitary gonadal axis in bipolar men.
作者信息
Kusalic M, Engelsmann F
机构信息
Department of Psychiatry, McGill University, Montreal, Quebec, Canada.
出版信息
J Psychiatry Neurosci. 1996 May;21(3):181-6.
This was a cross-sectional study assessing short- and long-term effects of lithium (Li) treatment on hormone levels. Levels of testosterone (T), prolactin (PRL), luteinizing hormone (LH), and follicule-stimulating hormone (FSH) were compared. Sixty-one lithium-treated, euthymic, stable, bipolar men were compared with 67 hospital controls and 22 healthy volunteers. Prolactin (P < or = 0.01) and luteinizing hormone (P < or = 0.001) were higher in all patients compared with healthy volunteers. Li-treated patients were evaluated at 22 to 24 mo, 2 to 5 y, and after more than 5 y of Li therapy. At 22 to 24 mo of Li treatment, levels of PRL and LH did not differ from the values of healthy volunteers or of patients treated for longer periods. In addition, the value of T was higher (P < or = 0.003) than in the group treated longer. Levels of T after more than 5 y of treatment, however, did not differ from those of the healthy volunteers.
这是一项横断面研究，旨在评估锂（Li）治疗对激素水平的短期和长期影响。比较了睾酮（T）、催乳素（PRL）、促黄体生成素（LH）和促卵泡激素（FSH）的水平。将61名接受锂治疗、心境正常、病情稳定的双相情感障碍男性与67名医院对照者和22名健康志愿者进行了比较。与健康志愿者相比，所有患者的催乳素（P≤0.01）和促黄体生成素（P≤0.001）水平更高。对接受锂治疗的患者在锂治疗22至24个月、2至5年以及超过5年之后进行了评估。在锂治疗22至24个月时，PRL和LH水平与健康志愿者或接受更长疗程治疗的患者的值没有差异。此外，T值高于（P≤0.003）接受更长疗程治疗的组。然而，治疗超过5年后的T水平与健康志愿者的T水平没有差异。
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