Bowers M B, Rozitis A
Eur J Pharmacol. 1982 Feb 19;78(1):113-5. doi: 10.1016/0014-2999(82)90378-8.
Lithium administered in chow produced a small increase in DA metabolites (DOPAC and HVA) in rat caudate but not cortex and augmented the increase in DA metabolites in both regions produced by haloperidol administration for 2 days. Given for 10 days with haloperidol, lithium attenuated the tolerance to an increase in DA metabolites in caudate. When administered with haloperidol for 22 days, lithium prevented the tolerance to catalepsy produced by daily administration of haloperidol alone. Lithium can augment and prolong the increase in regional DA metabolites and extend the duration of catalepsy produced by chronic haloperidol.
在大鼠的食物中添加锂会使尾状核中多巴胺代谢物（3,4-二羟基苯乙酸和高香草酸）略有增加，但不会使皮质中的多巴胺代谢物增加，并且会增强氟哌啶醇连续给药2天所引起的这两个脑区中多巴胺代谢物的增加。锂与氟哌啶醇一起给药10天，可减轻尾状核中多巴胺代谢物增加所产生的耐受性。当锂与氟哌啶醇一起给药22天时，可预防仅每日给予氟哌啶醇所产生的僵住症耐受性。锂可以增强并延长局部多巴胺代谢物的增加，并延长慢性给予氟哌啶醇所产生的僵住症持续时间。
