端点震颤诱导转换在克雅氏病中的预测价值。
The Predictive Value of Endpoint Quaking-Induced Conversion in Creutzfeldt-Jakob Disease.
机构信息
Department of Clinical Neurological Sciences, Schulich School of Medicine and Dentistry, Western University, London, Ontario, Canada.
Department of Pathology and Laboratory Medicine, Schulich School of Medicine and Dentistry, Western University, London, Ontario, Canada.
出版信息
Can J Neurol Sci. 2019 Sep;46(5):595-598. doi: 10.1017/cjn.2019.72. Epub 2019 Jul 3.
Creutzfeldt-Jakob disease (CJD) is a fatal neurological illness for which accurate diagnosis is paramount. Real-time quaking-induced conversion (RT-QuIC) is a prion-specific assay with high sensitivity and specificity for CJD. The Canadian endpoint quaking-induced conversion (EP-QuIC) test is similar, but unlike RT-QuIC there is little data regarding its diagnostic utility in clinical practice. In this exploratory predictive value analysis of EP-QuIC in CJD, the negative predictive value (NPV) and positive predictive value (PPV) was 100% and 83%, respectively, with one false-positive result identified. Re-testing this sample with an optimized EP-QuIC protocol eliminated this false-positive result, leading to a PPV of 100%.
克雅氏病（CJD）是一种致命的神经疾病，准确的诊断至关重要。实时震动诱导转化（RT-QuIC）是一种具有高灵敏度和特异性的朊病毒检测方法，可用于 CJD 的诊断。加拿大终点震动诱导转化（EP-QuIC）试验与之相似，但与 RT-QuIC 不同，关于其在临床实践中的诊断效用的数据较少。在这项关于 EP-QuIC 在 CJD 中的探索性预测价值分析中，阴性预测值（NPV）和阳性预测值（PPV）分别为 100%和 83%，只有一个假阳性结果。用优化的 EP-QuIC 方案重新检测该样本消除了这个假阳性结果，使 PPV 达到 100%。
Zotero 插件