Prion Diseases Section, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, Canada.
Division of Anatomical Pathology, University of Ottawa, Ottawa, Ontario, Canada.
Can J Neurol Sci. 2021 Jan;48(1):127-129. doi: 10.1017/cjn.2020.139. Epub 2020 Jul 10.
Prospectively acquired Canadian cerebrospinal fluid samples were used to assess the performance characteristics of three ante-mortem tests commonly used to support diagnoses of Creutzfeldt-Jakob disease. The utility of the end-point quaking-induced conversion assay as a test for Creutzfeldt-Jakob disease diagnoses was compared to that of immunoassays designed to detect increased amounts of the surrogate markers 14-3-3γ and hTau. The positive predictive values of the end-point quaking-induced conversion, 14-3-3γ, and hTau tests conducted at the Prion Diseases Section of the Public Health Agency of Canada were 96%, 68%, and 66%, respectively.
前瞻性采集的加拿大脑脊液样本用于评估三种常用于支持克雅氏病诊断的生前检测的性能特征。端点震颤诱导转换检测法作为克雅氏病诊断检测方法的实用性与设计用于检测替代标志物 14-3-3γ 和 hTau 增加量的免疫测定法进行了比较。加拿大公共卫生署朊病毒疾病科进行的端点震颤诱导转换、14-3-3γ 和 hTau 检测的阳性预测值分别为 96%、68%和 66%。
