Sorva R, Kuusi T, Taskinen M R, Perheentupa J, Nikkilä E A
Children's Hospital, Helsinki, Finland.
Atherosclerosis. 1988 Feb;69(2-3):191-7. doi: 10.1016/0021-9150(88)90014-7.
We studied the effects of testosterone substitution on serum concentrations of lipids, lipoproteins, apoproteins and on the activity of hepatic lipase (HL) and lipoprotein lipase (LPL) in postheparin plasma and on the activity of LPL in adipose tissue (AT-LPL) in 13 male hypopituitary patients. The activities of LPL and HL in postheparin plasma were markedly increased by 1 week after a testosterone enanthate injection (P less than 0.001). The HL activity remained elevated (P less than 0.05) after 1 month's treatment, but the LPL activity declined to presubstitution levels. The prolonged substitution decreased serum apoproteins A-I and A-II (P less than 0.05). The changes of apo A-I and A-II correlated inversely with those of the free testosterone index (FTI) (r = -0.74, r = -0.67, P less than 0.05). Serum HDL-cholesterol level decreased slightly by 1 week and it correlated inversely with the increase in testosterone and the FTI (r = -0.67, r = -0.85, P less than 0.05). The results suggest that testosterone increases the activity of both lipolytic enzymes in postheparin plasma. The effect on HL appears to be more persistent than that on LPL. The data support a role for androgens in the regulation of serum lipoprotein and HDL-cholesterol levels.
我们研究了睾酮替代疗法对13名男性垂体功能减退患者血脂、脂蛋白、载脂蛋白血清浓度的影响，以及对肝素后血浆中肝脂酶（HL）和脂蛋白脂酶（LPL）活性及脂肪组织中LPL活性（AT-LPL）的影响。庚酸睾酮注射1周后，肝素后血浆中LPL和HL的活性显著增加（P<0.001）。治疗1个月后，HL活性仍保持升高（P<0.05），但LPL活性降至替代前水平。长期替代治疗可降低血清载脂蛋白A-I和A-II（P<0.05）。载脂蛋白A-I和A-II的变化与游离睾酮指数（FTI）的变化呈负相关（r=-0.74，r=-0.67，P<0.05）。血清高密度脂蛋白胆固醇水平在1周时略有下降，且与睾酮和FTI的升高呈负相关（r=-0.67，r=-0.85，P<0.05）。结果表明，睾酮可增加肝素后血浆中两种脂解酶的活性。对HL的作用似乎比对LPL更持久。这些数据支持雄激素在调节血清脂蛋白和高密度脂蛋白胆固醇水平中起作用。
