Valdemarsson S, Hedner P, Nilsson-Ehle P
Acta Med Scand. 1987;221(4):363-6. doi: 10.1111/j.0954-6820.1987.tb03357.x.
Ten men with hypogonadism of pituitary origin were studied before and during testosterone substitution therapy with regard to effects on the activities of hepatic lipase (HL) and lipoprotein lipase (LPL) in postheparin plasma, and on plasma lipoprotein concentrations. The mean (+/- SEM) testosterone level increased from 1.8 +/- 0.5 to 16.3 +/- 2.4 nmol/l. The mean activity of HL rose from 327.1 +/- 35.2 to 432.8 +/- 57.2 mU/ml (p less than 0.02), while the activity of LPL did not change significantly, 71.0 +/- 9.1 mU/ml before and 62.2 +/- 3.8 mU/ml after treatment. No significant alterations in lipoprotein concentrations were recorded. These results indicate that a normal testosterone level is of importance for maintaining the activity of HL in men, thereby contributing to the sex difference previously recorded for HL activity.
对10名垂体性性腺功能减退男性在睾酮替代治疗前和治疗期间进行了研究，观察其对肝素后血浆中肝脂酶（HL）和脂蛋白脂肪酶（LPL）活性以及血浆脂蛋白浓度的影响。睾酮平均水平（±标准误）从1.8±0.5纳摩尔/升升至16.3±2.4纳摩尔/升。HL的平均活性从327.1±35.2毫微单位/毫升升至432.8±57.2毫微单位/毫升（P＜＞0.02），而LPL的活性无显著变化，治疗前为71.0±9.1毫微单位/毫升，治疗后为62.2±3.8毫微单位/毫升。脂蛋白浓度未记录到显著改变。这些结果表明，正常的睾酮水平对于维持男性HL的活性很重要，从而导致先前记录的HL活性的性别差异。
