Dipartimento di Scienze Mediche e Sanità Pubblica, Università di Cagliari, Cagliari, Italy.
Mailman School of Public Health, Columbia University, New York, NY, USA.
Braz J Psychiatry. 2020 Jan-Feb;42(1):63-67. doi: 10.1590/1516-4446-2018-0338.
To determine whether people with a Sardinian genetic background who live in the megacities of South America have a higher frequency of hypomania than residents of Sardinia.
A community survey of Sardinian immigrants was carried out in four Brazilian metropoles (n=218) and Buenos Aires (n=306). The results were compared with those of a study involving a similar methodology (Mood Disorder Questionnaire [MDQ] as a screening tool) conducted in seven Italian regions, including a sub-sample from Sardinia.
There was a higher prevalence of lifetime hypomania among Sardinians living in the Brazilian metropoles than among those living in Sardinia. This result was also consistent with Sardinian immigrants in Buenos Aires. After stratification by sex and age, the lifetime prevalence of MDQ scores ≥ 8 among Sardinians in South-American megacities and Sardinia was 8.6% vs. 2.9%, respectively (p < 0.0001).
The higher frequency of hypomania in migrant populations appears to favor an evolutionary view in which mood disorders may be a maladaptive aspect of a genetic background with adaptive characteristics.
确定生活在南美洲大城市的具有撒丁岛遗传背景的人群是否比撒丁岛居民更频繁地出现轻躁狂。
在四个巴西大都市（n=218）和布宜诺斯艾利斯（n=306）对撒丁岛移民进行了社区调查。将结果与一项涉及类似方法（心境障碍问卷[MDQ]作为筛选工具）的研究进行了比较，该研究在包括撒丁岛在内的七个意大利地区进行，其中包括一个子样本。
与生活在撒丁岛的撒丁岛人相比，生活在巴西大都市的撒丁岛人一生中出现轻躁狂的比例更高。这一结果也与布宜诺斯艾利斯的撒丁岛移民一致。经过性别和年龄分层后，南美大城市和撒丁岛撒丁岛人的 MDQ 评分≥8 的终生患病率分别为 8.6%和 2.9%（p<0.0001）。
移民人群中轻躁狂的更高频率似乎支持一种进化观点，即心境障碍可能是具有适应性特征的遗传背景的一种适应不良方面。
