David F, Intrator S, Foncin J F, Salmon D, Lucotte G
Centre national de Transfusion sanguine, Institut, Laboratoire de Génétique moléculaire, Paris.
C R Acad Sci III. 1988;306(1):1-4.
The hypothesis of a tight linkage between Alzheimer's disease (AD), a presenile dementia, and the probe coding for superoxide dismutase 1 (SOD 1), located on chromosome 21 at 21q22, has been investigated in a large family originating from Calabria, in which AD is transmitted as an autosomal dominant mendelian trait. Analysis of the Msp I restriction polymorphism, after molecular hybridization with the probe of DNAs coming from 22 subjects of the pedigree, allowed to the demonstrate that there wasn't any tight linkage between AD and the marker studied.
阿尔茨海默病（AD，一种早老性痴呆）与位于21号染色体21q22的超氧化物歧化酶1（SOD 1）编码探针之间存在紧密连锁的假说，已在一个来自卡拉布里亚的大家庭中进行了研究，在这个家族中，AD作为常染色体显性孟德尔性状遗传。在用来自该家系22名受试者的DNA探针进行分子杂交后，对Msp I限制性多态性进行分析，结果表明AD与所研究的标记之间不存在紧密连锁。
