David F, Hallé L, Lucotte G
C R Acad Sci III. 1987;305(2):21-4.
The hypothesis of an eventual linkage between Alzheimer's disease (AD), a presenile dementia, and the genomic probe GMG 21 S3, located on the long arm of chromosome 21, has been investigated in a large family originating from Calabria, in which AD is transmitted as an autosomal dominant mendelian trait. Analysis of the Bgl II restriction polymorphism, after molecular hybridization with the probe, of DNAs coming from 28 subjects of a pedigree, from which 10 individuals are affected, allowed to demonstrate that there wasn't any linkage between AD and the marker studied.
阿尔茨海默病（AD）是一种早老性痴呆，位于21号染色体长臂上的基因组探针GMG 21 S3与AD最终存在联系这一假说，已在一个来自卡拉布里亚的大家庭中进行了研究，在这个家族中，AD作为常染色体显性孟德尔性状遗传。对一个系谱中28名受试者的DNA进行分析，其中10人患病，在与该探针进行分子杂交后，分析Bgl II限制性多态性，结果表明AD与所研究的标记之间不存在任何联系。
