超越心尖部气球样改变：计算模型揭示应激性心肌病的形态学特征
Beyond apical ballooning: computational modelling reveals morphological features of Takotsubo cardiomyopathy.
作者信息
Pontecorboli Giulia, Biglino Giovanni, Milano Elena Giulia, Sophocleous Froso, Biffi Benedetta, Dastidar Amardeep Ghosh, Schievano Silvia, Di Mario Carlo, Bucciarelli-Ducci Chiara
机构信息
Bristol Heart Institute, University Hospitals Bristol NHS Trust , Bristol , UK.
Cardiovascular and Thoracic Department, Careggi University Hospital, Florence, Italy; Department of Experimental and Clinical Biomedical Sciences, University of Florence , Florence , Italy.
出版信息
Comput Methods Biomech Biomed Engin. 2019 Nov;22(14):1103-1106. doi: 10.1080/10255842.2019.1632836. Epub 2019 Jul 3.
Takotsubo cardiomyopathy (TCM) is characterized by transient myocardial dysfunction, typically at the left ventricular (LV) apex. Its pathophysiology and recovery mechanisms remain unknown. We investigated LV morphology and deformation in n = 28 TCM patients. Patients with MRI within 5 days from admission ("early TCM") showed reduced LVEF and higher ventricular volumes, but no differences in ECG, global strains or myocardial oedema. Statistical shape modelling described LV size (Mode 1), apical sphericity (Mode 2) and height (Mode 3). Significant differences in Mode 1 suggest that "early TCM" LV remodeling is mainly influenced by a change in ventricular size rather than apical sphericity.
应激性心肌病（TCM）的特征是短暂性心肌功能障碍，通常发生在左心室（LV）心尖部位。其病理生理学和恢复机制尚不清楚。我们对28例TCM患者的左心室形态和变形情况进行了研究。入院后5天内接受磁共振成像（MRI）检查的患者（“早期TCM”）表现出左心室射血分数（LVEF）降低和心室容积增大，但心电图、整体应变或心肌水肿方面无差异。统计形状建模描述了左心室大小（模式1）、心尖球形度（模式2）和高度（模式3）。模式1的显著差异表明，“早期TCM”左心室重塑主要受心室大小变化而非心尖球形度的影响。
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