[黑颈眼镜蛇毒液中的碱性磷脂酶具有细胞毒性]
[Basic phospholipase from the venom of Naja nigricollis is cytotoxic].
作者信息
Chwetzoff S, Takeshi M, Fromageot P, Ménez A
机构信息
Département de Biologie, C.E.N. Saclay, Gif-sur-Yvette.
出版信息
C R Acad Sci III. 1988;306(2):31-3.
PMID:3126984
Abstract
The basic phospholipase A2 purified from the venom of Naja nigricollis (Institut Pasteur), possesses an intense cytotoxic activity toward fetal cells from FL strain. At a concentration equal to 1.6 x 10(-6) M, the PLA2 lyses 50% of the cells present in a suspension containing 3.5 x 10(6) cells per millilitre. Other PLA2 from various origins do not exhibit such cytotoxic activity.
摘要
从黑颈眼镜蛇毒液（巴斯德研究所）中纯化得到的基本磷脂酶A2，对FL株胎儿细胞具有强烈的细胞毒性活性。在浓度等于1.6×10⁻⁶ M时，该磷脂酶A2可使每毫升含有3.5×10⁶个细胞的悬浮液中50%的细胞裂解。来自不同来源的其他磷脂酶A2则不表现出这种细胞毒性活性。
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