Després G, Romand R
Université Blaise-Pascal, Laboratoire de Neurobiologie, Ensemble scientifique des Cézeaux, Aubière.
C R Acad Sci III. 1988;306(3):135-8.
The presence of nerve growth factor (NGF) was investigated in the rat cochlea from birth to the adult stage, using immunohistochemical techniques NGF-like protein could be detected in the organ of Corti from birth up to day 8 and located within the hair cells, above the nuclei. No NGF-like immunoreactivity could be detected in the spiral ganglion. These results suggest that NGF may have a neurotropic action in the developing rat cochlea.
利用免疫组织化学技术，对出生至成年阶段大鼠耳蜗中神经生长因子（NGF）的存在情况进行了研究。从出生到第8天，在柯蒂氏器中可检测到NGF样蛋白，其位于毛细胞内、细胞核上方。在螺旋神经节中未检测到NGF样免疫反应性。这些结果表明，NGF可能在发育中的大鼠耳蜗中具有神经营养作用。
