Ito Nanao, Yoshida Toshinori, Ichikawa Rho, Makino Emi, Akema Satoshi, Fukumori Junko, Takahashi Naofumi, Nakahara Junta, Yamashita Risako, Orihara Kai, Kobayashi Mio, Xiantao Hou, Watanabe Yousuke, Mizukami Sayaka, Shibutani Makoto
Hirakawa Zoological Park, 5669-1 Hirakawa-cho, Kagoshima-shi, Kagoshima 891-0133, Japan.
Laboratory of Veterinary Pathology, Tokyo University of Agriculture and Technology, 3-5-8 Saiwai-cho, Fuchu-shi, Tokyo 183-8509, Japan.
J Vet Med Sci. 2019 Aug 24;81(8):1229-1233. doi: 10.1292/jvms.19-0006. Epub 2019 Jul 2.
A female koala presented with hyperglycemia related to diabetes mellitus diagnosed at 9 years and treated with insulin. She presented with nasal hemorrhage, anemia, leukocytosis, and tachypnea at 10 years. A blood smear examination revealed scattered, atypical large myeloid cells and a clinical diagnosis of myelogenous leukemia was made. White blood cell count reached a maximum of 295 × 10/µl, with evidence of severe regenerative anemia and thrombocytopenia. Grossly, systemic lymph node enlargement, fragile liver with hemorrhage, and bloody ascites were observed. Histopathologically, atypical myeloid cells, including myelocytic and metamyelocytic cells, were scattered in the vasculature and surrounding tissues throughout the organs. The patient was infected with a koala retrovirus, which might have caused the myelogenous leukemia.
一只雌性考拉因9岁时被诊断出患有糖尿病并接受胰岛素治疗而出现高血糖。它在10岁时出现鼻出血、贫血、白细胞增多和呼吸急促。血液涂片检查发现散在的非典型大髓细胞，临床诊断为髓性白血病。白细胞计数最高达到295×10/µl，有严重再生性贫血和血小板减少的证据。大体观察，可见全身淋巴结肿大、肝脏脆弱伴出血以及血性腹水。组织病理学检查显示，包括髓细胞和晚幼粒细胞在内的非典型髓细胞散在于各器官的血管系统和周围组织中。该患者感染了考拉逆转录病毒，这可能导致了髓性白血病。
